Rabbit anti-Human UBXN6 Polyclonal Antibody | anti-UBXN6 antibody
UBXN6 Antibody
Gene Names
UBXN6; UBXD1; UBXDC2
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
UBXN6; Polyclonal Antibody; UBXN6 Antibody; UBX domain containing 1; UBX domain containing 2; UBX domain containing protein 1; UBX domain containing protein 6; UBX domain protein 6; UBX domain-containing protein 1; UBX domain-containing protein 6; UBXD1; UBXDC2; Ubxn6; UBXN6_HUMAN; anti-UBXN6 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
UBXN6 Antibody detects endogenous levels of UBXN6.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-UBXN6 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human UBXN6.
Conjugation
Unconjugated
Similarity
The UBX domain lacks key residues critical for VCP binding.
Subunit Structure
Interacts with VCP through the PUB domain (via C-terminus) and VIM motif (via N-terminus); the interaction is direct. Forms a ternary complex with CAV1 and VCP. Interacts with SYVN1. Interacts with HERPUD1. Interacts with VCPKMT. May interact with DERL1. Interacts with PLAA, VCP and YOD1; may form a complex involved in macroautophagy. Interacts with LMAN1.
Tissue Specificity
Enhanced expression in testis.
Function
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.
Note
Localizes at the centrosome both in interphase and during mitosis (PubMed:18656546). May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP (PubMed:21822278). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-UBXN6 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
441
NCBI Official Full Name
UBX domain-containing protein 6
NCBI Official Synonym Full Names
UBX domain protein 6
NCBI Official Symbol
UBXN6
NCBI Official Synonym Symbols
UBXD1; UBXDC2
NCBI Protein Information
UBX domain-containing protein 6; UBX domain containing 1; UBX domain-containing 1; UBX domain-containing 2; UBX domain-containing protein 1
UniProt Protein Name
UBX domain-containing protein 6
UniProt Gene Name
UBXN6
UniProt Synonym Gene Names
UBXD1; UBXDC2
UniProt Entry Name
UBXN6_HUMAN
Uniprot Description
UBXN6: Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 19p13
Cellular Component: cytoplasm; nucleolus; microtubule organizing center; nucleus
Molecular Function: protein binding
Research Articles on UBXN6
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Product Notes
The UBXN6 ubxn6 (Catalog #AAA9630226) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The UBXN6 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's UBXN6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the UBXN6 ubxn6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "UBXN6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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