Rabbit anti-Human, Mouse UBXN6 Polyclonal Antibody | anti-UBXN6 antibody

UBXN6, CT (UBXN6, UBXD1, UBXDC2, UBX domain-containing protein 6, UBX domain-containing protein 1) (FITC)

Cat. Num. AAA6361039

• Gene Names: UBXN6; UBXD1; UBXDC2
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: UBXN6; Polyclonal Antibody; CT (UBXN6; UBXD1; UBXDC2; UBX domain-containing protein 6; UBX domain-containing protein 1) (FITC); UBX domain-containing protein 1; anti-UBXN6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-UBXN6 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:50-100; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: UBXN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-320 amino acids from the C-terminal region of human UBXN6.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of UBXN6 Antibody (C-term) in mouse kidney tissue lysates (35ug/lane).UBXN6 (arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(UBXN6 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded mouse testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the UBXN6 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-UBXN6 antibody

UBXN6 acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. UBXN6 is MDM2 stabilization leads to MDM2-dependent TP53 degradation.

Product Categories/Family for anti-UBXN6 antibody

Antibodies; Proteins

References

Nagahama, M., et al. Biochem. Biophys. Res. Commun. 382(2):303-308(2009). Kern, M., et al. Biochem. Biophys. Res. Commun. 380(2):303-307(2009). Madsen, L., et al. Int. J. Biochem. Cell Biol. 40(12):2927-2942(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 30913412
• NCBI GeneID: 80700
• UniProt Accession #: Q9BZV1; Q96AH1; Q96IK9; Q9BZV0; D6W626
• Molecular Weight: 441
• NCBI Official Full Name: UBX domain-containing protein 6
• NCBI Official Synonym Full Names: UBX domain protein 6
• NCBI Official Symbol: UBXN6
• NCBI Official Synonym Symbols: UBXD1; UBXDC2
• NCBI Protein Information: UBX domain-containing protein 6; UBX domain containing 1; UBX domain-containing 1; UBX domain-containing 2; UBX domain-containing protein 1
• UniProt Protein Name: UBX domain-containing protein 6
• UniProt Gene Name: UBXN6
• UniProt Synonym Gene Names: UBXD1; UBXDC2
• UniProt Entry Name: UBXN6_HUMAN

Uniprot Description

UBXN6: Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: cytoplasm; nucleolus; microtubule organizing center; nucleus

Molecular Function: protein binding