Rabbit anti-Human, Mouse UBP1 Polyclonal Antibody | anti-UBP1 antibody

UBP1 Antibody

Cat. Num. AAA9412285

• Gene Names: UBP1; LBP1A; LBP1B; LBP-1B; LBP-1a
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: UBP1; Polyclonal Antibody; UBP1 Antibody; LBP1A; LBP1B; LBP-1B; LBP-1a; anti-UBP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total UBP1 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2.7 mg/ml (varies by lot)
• Sequence Length: 504

• Applicable Applications for anti-UBP1 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human upstream binding protein 1
• Target Name: UBP1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human ovarain cancer tissue using at dilution 1/40.)

Related Product Information for anti-UBP1 antibody

LBP1 (Upstream-binding protein 1), also designated UBP1, LBP1A or LBP1B, is a 540 amino acid protein that belongs to the grh/CP2 family (grainyhead transcription factor family). LBP1 is a transcriptional activator that regulates the placental expression of CYP11A1 and activates the Hemoglobin globin promoter in erythroid cells. LBP1 is responsible for repressing transcription of HIV-1 by binding to and preventing TFIID from interacting with its promoter region. Null expression of LBP1 causes uterine growth retardation in mice embryos suggesting a critical role in extraembryonic angiogenesis. LBP1 localizes to the nucleus and is expressed in adrenal tissue, Hep G2, JEG-3, and HeLa cell lines. It forms two natural variants by alternative splicing. LBP1 can form homodimers as well as heterodimers with LBP-9. LBP-9 suppresses the expression of LBP1.

Product Categories/Family for anti-UBP1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 189491632
• NCBI GeneID: 7342
• NCBI Accession #: NP_001121632.1
• NCBI GenBank Nucleotide #: NM_001128160.1
• UniProt Accession #: Q9NZI7; Q68CT0; Q86Y57; Q9H8V0; Q9UD76; Q9UD78
• Molecular Weight: 56,453 Da
• NCBI Official Full Name: upstream-binding protein 1 isoform LBP-1a
• NCBI Official Synonym Full Names: upstream binding protein 1 (LBP-1a)
• NCBI Official Symbol: UBP1
• NCBI Official Synonym Symbols: LBP1A; LBP1B; LBP-1B; LBP-1a
• NCBI Protein Information: upstream-binding protein 1
• UniProt Protein Name: Upstream-binding protein 1
• Protein Family: UBP1-associated protein
• UniProt Gene Name: UBP1
• UniProt Synonym Gene Names: LBP1
• UniProt Entry Name: UBIP1_HUMAN

Uniprot Description

UBP1: Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. Belongs to the grh/CP2 family. CP2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; angiogenesis; viral genome replication; negative regulation of transcription, DNA-dependent