Western Blot (WB)
(U119B Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the U119B antibody detected the U119B protein (arrow).)
Rabbit U119B Polyclonal Antibody | anti-UNC119B antibody
U119B Antibody (C-term)
Gene Names
UNC119B; POC7B
Reactivity
Human, mouse (Predicted Reactivity: Zebrafish, Xenopus)
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
U119B; Polyclonal Antibody; U119B Antibody (C-term); Protein unc-119 homolog B; UNC119B; anti-UNC119B antibody
Host
Rabbit
Reactivity
Human, mouse (Predicted Reactivity: Zebrafish, Xenopus)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This U119B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-236 amino acids from the C-terminal region of human U119B.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
207-236
Sequence Length
251
Applicable Applications for anti-UNC119B antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Region
207-236
Function
Myristoyl-binding protein that acts as a cargoadapter: specifically binds the myristoylmoiety of a subset of N-terminallymyristoylated proteins and is required fortheir localization. Binds myristoylated NPHP3and plays a key role in localization of NPHP3to the primary cilium membrane. Does notbind all myristoylated proteins. Probablyplays a role in trafficking proteins inphotoreceptor cells.
Cellular Location
Cell projection, cilium. Note=Enriched at thetransition zone and extended into theproximal end of the cilium
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(U119B Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the U119B antibody detected the U119B protein (arrow).)
Western Blot (WB)
(U119B Antibody (C-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the U119B antibody detected the U119B protein (arrow).)
TD
(All lanes : U119B Antibody (C-term) at 1:1000 dilution Lane 1: human kidney lysate Lane 2: human liver lysate Lysates/proteins at20 ?g per lane. Secondary Goat Anti-RabbitIgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)
TD
(All lanes : U119B Antibody (C-term) at 1:1000 dilution Lane 1: human kidney lysate Lane 2: human liver lysate Lysates/proteins at20 ?g per lane. Secondary Goat Anti-RabbitIgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 28 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)
Product Categories/Family for anti-UNC119B antibody
References
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Scherer, S.E., et al. Nature 440(7082):346-351(2006)
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Scherer, S.E., et al. Nature 440(7082):346-351(2006)
Venter, J.C., et al. Science 291(5507):1304-1351(2001)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
protein unc-119 homolog B
NCBI Official Synonym Full Names
unc-119 lipid binding chaperone B
NCBI Official Symbol
UNC119B
NCBI Official Synonym Symbols
POC7B
NCBI Protein Information
protein unc-119 homolog B
UniProt Protein Name
Protein unc-119 homolog B
Protein Family
UniProt Gene Name
UNC119B
UniProt Entry Name
U119B_HUMAN
Uniprot Description
UNC119B: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells. Belongs to the PDE6D/unc-119 family.
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: cytosol
Molecular Function: protein binding; lipid binding
Biological Process: lipoprotein transport; organelle organization and biogenesis
Research Articles on UNC119B
Similar Products
Product Notes
The UNC119B unc119b (Catalog #AAA9204495) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 207-236. The U119B Antibody (C-term) reacts with Human, mouse (Predicted Reactivity: Zebrafish, Xenopus) and may cross-react with other species as described in the data sheet. AAA Biotech's U119B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the UNC119B unc119b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "U119B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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