Rabbit anti-Human TYRP1 Polyclonal Antibody | anti-TYRP1 antibody

TYRP1, ID (TYRP1, CAS2, TYRP, TYRRP, 5,6-dihydroxyindole-2-carboxylic acid oxidase, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1) (MaxLight 650)

Cat. Num. AAA6360461

• Gene Names: TYRP1; TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TYRP1; Polyclonal Antibody; ID (TYRP1; CAS2; TYRP; TYRRP; 5; 6-dihydroxyindole-2-carboxylic acid oxidase; Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1) (MaxLight 650); Tyrosinase-related protein 1; anti-TYRP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-TYRP1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TYRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-371 amino acids from the Central region of human TYRP1.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-TYRP1 antibody

This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III.

Product Categories/Family for anti-TYRP1 antibody

Antibodies; Disease Markers

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Rausch, M.P., et al. J. Immunol. 185(5):2828-2835(2010). Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010): Edwards, M., et al. PLoS Genet. 6 (3), E1000867 (2010): Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4507757
• NCBI GeneID: 7306
• NCBI Accession #: NP_000541.1
• NCBI GenBank Nucleotide #: NM_000550.2
• UniProt Accession #: P17643; P78468; P78469; Q13721; Q15679
• NCBI Official Full Name: 5,6-dihydroxyindole-2-carboxylic acid oxidase
• NCBI Official Synonym Full Names: tyrosinase related protein 1
• NCBI Official Symbol: TYRP1
• NCBI Official Synonym Symbols: TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
• NCBI Protein Information: 5,6-dihydroxyindole-2-carboxylic acid oxidase
• UniProt Protein Name: 5,6-dihydroxyindole-2-carboxylic acid oxidase
• Protein Family: 5,6-dihydroxyindole-2-carboxylic acid oxidase
• UniProt Gene Name: TYRP1
• UniProt Synonym Gene Names: CAS2; TYRP; TYRRP; DHICA oxidase; TRP; TRP-1; TRP1

NCBI Description

This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]

Uniprot Description

TYRP1: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3); also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Belongs to the tyrosinase family.

Protein type: Amino Acid Metabolism - tyrosine; EC 1.14.18.-; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: 9p23

Cellular Component: endosome membrane; melanosome; melanosome membrane

Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: positive regulation of melanin biosynthetic process

Disease: Albinism, Oculocutaneous, Type Iii; Skin/hair/eye Pigmentation, Variation In, 11