Rabbit Tyk2 Polyclonal Antibody | anti-Tyk2 antibody

Tyk2 Polyclonal Antibody

Cat. Num. AAA3013624

• Gene Names: TYK2; JTK1; IMD35
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunocytochemistry, Immunohistochemistry, Flow Cytometry, Functional Assay
• Purity: Protein affinity purified.
• Synonyms: Tyk2; Polyclonal Antibody; Tyk2 Polyclonal Antibody; TYK2; JTK 1; JTK1; Non receptor tyrosine protein kinase 2; Non receptor tyrosine protein kinase TYK2; Non-receptor tyrosine-protein kinase TYK2; OTTHUMP00000232745; OTTHUMP00000232746; OTTHUMP00000232748; Protein Tyrosine Kinase 2; TYK 2; Tyrosine kinase 2; anti-Tyk2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Tyk2 polyclonal antibody detects endogenous levels of Tyk2 protein.
• Purity/Purification: Protein affinity purified.
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1187

• Applicable Applications for anti-Tyk2 antibody: Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
• Application Notes: WB: 1:500; ICC: 1:50-1:200; IHC: 1:50-1:200; FC/FACS: 1:50-1:100
• Immunogen: Recombinant protein within human TYK2 aa 400-600.
• Preparation and Storage: Store at 4 degree C after thawing.; Aliquot store at -20 degree C.; Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of TYK2 on MCF-7 cell lysate using anti-TYK2 antibody at 1/500 dilution.)

Immunocytochemistry (ICC)

(ICC staining TYK2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)

Related Product Information for anti-Tyk2 antibody

TYK2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where TYK2 is associated. TYK2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.

NCBI and Uniprot Product Information

• NCBI GI #: 187608615
• NCBI GeneID: 7297
• NCBI Accession #: NP_003322.3
• NCBI GenBank Nucleotide #: NP_003322.3
• UniProt Accession #: P29597; Q9R117
• Molecular Weight: 134kDa
• NCBI Official Full Name: non-receptor tyrosine-protein kinase TYK2
• NCBI Official Synonym Full Names: tyrosine kinase 2
• NCBI Official Symbol: TYK2
• NCBI Official Synonym Symbols: JTK1; IMD35
• NCBI Protein Information: non-receptor tyrosine-protein kinase TYK2
• UniProt Protein Name: Non-receptor tyrosine-protein kinase TYK2
• Protein Family: Non-receptor tyrosine-protein kinase
• UniProt Gene Name: TYK2
• UniProt Entry Name: TYK2_HUMAN

NCBI Description

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]