Goat TXNDC11 Polyclonal Antibody | anti-TXNDC11 antibody

Goat Polyclonal to Human TXNDC11

Cat. Num. AAA248046

• Gene Names: TXNDC11; EFP1
• Reactivity: Gibbon, Gorilla, Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: TXNDC11; Polyclonal Antibody; Goat Polyclonal to Human TXNDC11; Anti-TXNDC11 Antibody (Internal) IHC-plus; EF-hand binding protein 1; EF-hand-binding protein 1; EFP1; Human TXNDC11; anti-TXNDC11 antibody

• Host: Goat
• Reactivity: Gibbon, Gorilla, Human
• Clonality: Polyclonal
• Specificity: Human TXNDC11.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 958

• Applicable Applications for anti-TXNDC11 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:16000), IHC-P (5 ug/ml), WB (1 - 3 ug/ml); Usage: Peptide ELISA: antibody detection limit dilution 1:16000. Western blot: Approx 100kD band observed in Human Spleen and Thymus lysates (calculated MW of 108kD according to NP_056998.4). Recommended concentration: 1-3 ug/ml.
• Target Species: Human
• Immunogen Description: Synthetic peptide C-QLDYAEYVRRDSE from an internal region of human TXNDC11 (NP_056998.4). Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%); Marmoset, Panda, Dog, Horse, Opossum (92%); Monkey, Elephant, Bat, Bovine, Xenopus (85%).
• Immunogen Type: Synthetic peptide
• Immunogen: TXNDC11 antibody was raised against synthetic peptide C-QLDYAEYVRRDSE from an internal region of human TXNDC11 (NP_056998.4). Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%); Marmoset, Panda, Dog, Horse, Opossum (92%); Monkey, Elephant, Bat, Bovine, Xenopus (85%).
• Antigen Modification: Internal
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Human, Small intestine: Formalin-Fixed Paraffin-Embedded (FFPE))

Western Blot (WB)

(TXNDC11 antibody (1 ug/ml) staining of Human Thymus lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

NCBI and Uniprot Product Information

• NCBI GI #: 54633317
• NCBI GeneID: 51061
• NCBI Accession #: NP_056998.4
• NCBI GenBank Nucleotide #: NM_015914.6
• UniProt Accession #: Q6PKC3; O95887; Q6PJA6; Q8N2Q4; Q96K45; Q96K53
• Molecular Weight: 30,375 Da
• NCBI Official Full Name: thioredoxin domain-containing protein 11 isoform 2
• NCBI Official Synonym Full Names: thioredoxin domain containing 11
• NCBI Official Symbol: TXNDC11
• NCBI Official Synonym Symbols: EFP1
• NCBI Protein Information: thioredoxin domain-containing protein 11; EF-hand binding protein 1; EF-hand-binding protein 1
• UniProt Protein Name: Thioredoxin domain-containing protein 11
• Protein Family: Thioredoxin domain-containing protein
• UniProt Gene Name: TXNDC11
• UniProt Synonym Gene Names: EFP1
• UniProt Entry Name: TXD11_HUMAN

Uniprot Description

TXNDC11: May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation. Belongs to the protein disulfide isomerase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.13

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: protein folding; cell redox homeostasis