Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TWIST2 Polyclonal Antibody at dilution 1:35)
Rabbit TWIST2 Polyclonal Antibody | anti-TWIST2 antibody
TWIST2 Polyclonal Antibody
IHC: 1:25-100
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TWIST2 Polyclonal Antibody at dilution 1:35)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TWIST2 Polyclonal Antibody at dilution 1:35)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014]
Uniprot Description
TWIST2: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors. Defects in TWIST2 are the cause of Setleis syndrome (SETLEISS). A focal facial dermal dysplasia characterized by distinctive bitemporal scar-like depressions resembling forceps marks, and additional facial features, including a coarse and leonine appearance, absent eyelashes on both lids or multiple rows on the upper lids, absent Meibomian glands, slanted eyebrows, chin clefting, and hypo- or hyperpigmentation of the skin. Histologically, the bitemporal lesion is an ectodermal dysplasia with near absence of subcutaneous fat, suggesting insufficient migration of neural crest cells into the frontonasal process and the first branchial arch.
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding
Biological Process: negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent
Disease: Ablepharon-macrostomia Syndrome; Barber-say Syndrome; Focal Facial Dermal Dysplasia 3, Setleis Type
Research Articles on TWIST2
Similar Products
Product Notes
The TWIST2 twist2 (Catalog #AAA2542580) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TWIST2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TWIST2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). ELISA: 1:2000-5000 IHC: 1:25-100. Researchers should empirically determine the suitability of the TWIST2 twist2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TWIST2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
