Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embeded human placenta using MBS7002046 at dilution of 1:100)
Rabbit anti-Human Tumor necrosis factor ligand superfamily member 9 Polyclonal Antibody | anti-TNFSF9 antibody
Rabbit anti-human Tumor necrosis factor ligand superfamily member 9 polyclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embeded human placenta using MBS7002046 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embeded human placenta using MBS7002046 at dilution of 1:100)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
Uniprot Description
TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family.
Protein type: Apoptosis; Membrane protein, integral; Cytokine; Cell cycle regulation
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: extracellular space; integral to membrane; plasma membrane
Molecular Function: cytokine activity; receptor binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding
Biological Process: apoptosis; cell proliferation; cell-cell signaling; immune response; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; signal transduction
Research Articles on TNFSF9
Similar Products
Product Notes
The TNFSF9 tnfsf9 (Catalog #AAA7002046) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Tumor necrosis factor ligand superfamily member 9 polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Tumor necrosis factor ligand superfamily member 9 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC: 1:20-1:200. Researchers should empirically determine the suitability of the TNFSF9 tnfsf9 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Tumor necrosis factor ligand superfamily member 9, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
