Rabbit anti-Human Tubulin beta-2B Chain Polyclonal Antibody | anti-TUBB2B antibody

Tubulin beta-2B Chain (TUBB2B, bA506K6.1, PMGYSA, RP11-506K6.1)

Cat. Num. AAA6003080

• Gene Names: TUBB2B; PMGYSA; bA506K6.1; RP11-506K6.1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: Tubulin beta-2B Chain; Polyclonal Antibody; Tubulin beta-2B Chain (TUBB2B; bA506K6.1; PMGYSA; RP11-506K6.1); Anti -Tubulin beta-2B Chain (TUBB2B; anti-TUBB2B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TUBB2B.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA

• Applicable Applications for anti-TUBB2B antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human TUBB2B, aa1-445 (NP_821080.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of TUBB2B expression in transfected 293T cell line by TUBB2B polyclonal antibody. Lane 1: TUBB2B transfected lysate (5kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-TUBB2B antibody

Antibodies; Abs to Tubulin

NCBI and Uniprot Product Information

• NCBI GI #: 29788768
• NCBI GeneID: 347733
• NCBI Accession #: NP_821080.1
• NCBI GenBank Nucleotide #: NM_178012.4
• UniProt Accession #: Q9BVA1; A8K068
• Molecular Weight: 49,953 Da
• NCBI Official Full Name: tubulin beta-2B chain
• NCBI Official Synonym Full Names: tubulin, beta 2B class IIb
• NCBI Official Symbol: TUBB2B
• NCBI Official Synonym Symbols: PMGYSA; bA506K6.1; RP11-506K6.1
• NCBI Protein Information: tubulin beta-2B chain; class IIb beta-tubulin; class II beta-tubulin isotype; tubulin, beta polypeptide paralog
• UniProt Protein Name: Tubulin beta-2B chain
• Protein Family: Tubulin
• UniProt Gene Name: TUBB2B
• UniProt Entry Name: TBB2B_HUMAN

NCBI Description

The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]

Uniprot Description

TUBB2B: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB2B is implicated in neuronal migration. Defects in TUBB2B are a cause of polymicrogyria asymmetric (PMGA). PMGA is a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination. Belongs to the tubulin family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: microtubule; cytoplasm; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; neuron migration; transmembrane transport; microtubule-based process

Disease: Polymicrogyria, Symmetric Or Asymmetric