Mouse anti-Human TUBB2B Monoclonal Antibody | anti-TUBB2B antibody

Mouse Monoclonal [clone AT5B3] (Ig2a,k) to Human TUBB2B

Cat. Num. AAA246257

• Gene Names: TUBB2B; PMGYSA; bA506K6.1
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein G Purified
• Synonyms: TUBB2B; Monoclonal Antibody; Mouse Monoclonal [clone AT5B3] (Ig2a; k) to Human TUBB2B; Anti-TUBB2B Antibody (clone AT5B3) IHC-plus; BA506K6.1; Class IIb beta-tubulin; PMGYSA; RP11-506K6.1; Tubulin; beta 2B; Class II beta-tubulin isotype; Tubulin beta-2B chain; beta 2B class IIb; Human TUBB2B; anti-TUBB2B antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Ig2a,k
• Clone Number: AT5B3
• Purity/Purification: Protein G Purified
• Form/Format: Phosphate buffered saline, pH 7.4, 0.1% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 445

• Applicable Applications for anti-TUBB2B antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: Recombinant human TUBB2b (aa1-445) purified from E Coli
• Immunogen Type: Recombinant protein
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-TUBB2B antibody IHC of human colon, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-TUBB2B antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 29788768
• NCBI GeneID: 347733
• NCBI Accession #: NP_821080.1
• NCBI GenBank Nucleotide #: NM_178012.4
• UniProt Accession #: Q9BVA1; A8K068
• Molecular Weight: 49,953 Da
• NCBI Official Full Name: tubulin beta-2B chain
• NCBI Official Synonym Full Names: tubulin, beta 2B class IIb
• NCBI Official Symbol: TUBB2B
• NCBI Official Synonym Symbols: PMGYSA; bA506K6.1
• NCBI Protein Information: tubulin beta-2B chain; class IIb beta-tubulin; class II beta-tubulin isotype; tubulin, beta polypeptide paralog
• UniProt Protein Name: Tubulin beta-2B chain
• Protein Family: Tubulin
• UniProt Gene Name: TUBB2B
• UniProt Entry Name: TBB2B_HUMAN

NCBI Description

The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]

Uniprot Description

TUBB2B: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB2B is implicated in neuronal migration. Defects in TUBB2B are a cause of polymicrogyria asymmetric (PMGA). PMGA is a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination. Belongs to the tubulin family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: microtubule; cytoplasm; nucleus

Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; neuron migration; transmembrane transport; microtubule-based process

Disease: Polymicrogyria, Symmetric Or Asymmetric