TUBA4A Polyclonal Antibody | anti-TUBA4A antibody

Tubulin-4A Alpha Chain Polyclonal Antibody

Cat. Num. AAA448082

• Gene Names: TUBA4A; ALS22; TUBA1; H2-ALPHA
• Reactivity: Reacts against human, rat, mouse, monkey and canine proteins.
• Applications: Western Blot
• Purity: Epitope Affinity Purified
• Synonyms: TUBA4A; Polyclonal Antibody; Tubulin-4A Alpha Chain Polyclonal Antibody; TUBA1; TUBA4A antibody; anti-TUBA4A antibody

• Reactivity: Reacts against human, rat, mouse, monkey and canine proteins.
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This antibody gives a positive signal in the following human (HeLa), rat (NRK), mouse (AtT-20), dog (MDCK) whole cell lysates.
• Purity/Purification: Epitope Affinity Purified
• Form/Format: Polyclonal antibody supplied as a 200 ul (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.
• Sequence Length: 433

• Applicable Applications for anti-TUBA4A antibody: Western Blot (WB)
• Application Notes: Western Blot: 1:500-1:2,000
• Source: Goat
• Handling: The antibody solution should be gently mixed before use.
• Conjugation: Unconjugated
• Antigen: Purified recombinant peptide derived from within residues 80 aa to the N-terminus of human alpha tubulin produced in E. coli.
• Preparation and Storage: Store at -20 C for long-term storage. Store at 2-8 C for up to one month. Avoid freeze/thaw cycles.

Testing Data

Related Product Information for anti-TUBA4A antibody

Goat polyclonal antibody to alpha tubulin. Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly.

NCBI and Uniprot Product Information

• NCBI GI #: 514052659
• NCBI GeneID: 7277
• NCBI Accession #: NP_001265481.1
• NCBI GenBank Nucleotide #: NM_001278552.1
• NCBI Official Full Name: tubulin alpha-4A chain isoform 2
• NCBI Official Synonym Full Names: tubulin, alpha 4a
• NCBI Official Symbol: TUBA4A
• NCBI Official Synonym Symbols: ALS22; TUBA1; H2-ALPHA
• NCBI Protein Information: tubulin alpha-4A chain; tubulin H2-alpha; tubulin alpha-1 chain; tubulin, alpha 1 (testis specific)
• UniProt Protein Name: Tubulin alpha-4A chain
• Protein Family: Tubulin
• UniProt Gene Name: TUBA4A
• UniProt Synonym Gene Names: TUBA1
• UniProt Entry Name: TBA4A_HUMAN

NCBI Description

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Uniprot Description

TUBA4A: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. Dimer of alpha and beta chains. Belongs to the tubulin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: microtubule; extracellular region; cytosol

Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton

Biological Process: protein polymerization; 'de novo' posttranslational protein folding; platelet activation; cellular protein metabolic process; platelet degranulation; protein folding; organelle organization and biogenesis; mitotic cell cycle; G2/M transition of mitotic cell cycle; blood coagulation; microtubule-based process

Disease: Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia