Rabbit anti-Human TTPA Polyclonal Antibody | anti-TTPA antibody

TTPA, ID (TTPA, TPP1, Alpha-tocopherol transfer protein) (Biotin)

Cat. Num. AAA6360070

• Gene Names: TTPA; ATTP; AVED; TTP1; alphaTTP
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TTPA; Polyclonal Antibody; ID (TTPA; TPP1; Alpha-tocopherol transfer protein) (Biotin); Alpha-tocopherol transfer protein; anti-TTPA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-TTPA antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TTPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the Central region of human TTPA.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TTPA Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TTPA antibody detected the TTPA protein (arrow).)

Related Product Information for anti-TTPA antibody

This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa.

Product Categories/Family for anti-TTPA antibody

Antibodies; Disease Markers

References

Zhang, W.X., et al. Lipids 44(7):631-641(2009). Wright, M.E., et al. Cancer Res. 69(4):1429-1438(2009). Fusco, C., et al. J. Child Neurol. 23(11):1328-1330(2008). Rotzoll, D.E., et al. Eur. J. Obstet. Gynecol. Reprod. Biol. 140(2):183-191(2008). Kara, B., et al. Turk. J. Pediatr. 50(5):471-475(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 4507723
• NCBI GeneID: 7274
• NCBI Accession #: NP_000361.1
• NCBI GenBank Nucleotide #: NM_000370.3
• UniProt Accession #: P49638; Q71V64
• Molecular Weight: 31,750 Da
• NCBI Official Full Name: alpha-tocopherol transfer protein
• NCBI Official Synonym Full Names: alpha tocopherol transfer protein
• NCBI Official Symbol: TTPA
• NCBI Official Synonym Symbols: ATTP; AVED; TTP1; alphaTTP
• NCBI Protein Information: alpha-tocopherol transfer protein
• UniProt Protein Name: Alpha-tocopherol transfer protein
• Protein Family: Alpha-tocopherol transfer protein
• UniProt Gene Name: TTPA
• UniProt Synonym Gene Names: TPP1; Alpha-TTP

NCBI Description

This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]

Uniprot Description

Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol ().