Western Blot (WB)
(Western blot analysis of TTC19 expression in A431 whole cell lysate,The lane on the left is treated with the antigen-specific peptide.)
Rabbit anti-Human, Mouse TTC19 Polyclonal Antibody | anti-TTC19 antibody
TTC19 Antibody
Western Blot (WB)
(Western blot analysis of TTC19 expression in A431 whole cell lysate,The lane on the left is treated with the antigen-specific peptide.)
Western Blot (WB)
(Western blot analysis of TTC19 expression in A431 whole cell lysate,The lane on the left is treated with the antigen-specific peptide.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein with a tetratricopeptide repeat (TPR) domain containing several TPRs of about 34 aa each. These repeats are found in a variety of organisms including bacteria, fungi and plants, and are involved in a variety of functions including protein-protein interactions. This protein is embedded in the inner mitochondrial membrane and is involved in the formation of the mitochondrial respiratory chain III. It has also been suggested that this protein plays a role in cytokinesis. Mutations in this gene cause mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2012]
Uniprot Description
TTC19: Mitochondrial protein required for formation of the mitochondrial complex III (PubMed:21278747). May also be required for the abcission step in cytokinesis, possibly regulating the ESCRT-III complex via its interaction with CHMP4B (PubMed:20208530). However, the involvement in cytokinesis requires additional experimental evidence. Defects in TTC19 are a cause of mitochondrial complex III deficiency (MT-C3D). A disorder of the mitochondrial respiratory chain resulting in a highly variable phenotype depending on which tissues are affected. Clinical features include mitochondrial encephalopathy, psychomotor retardation, ataxia, severe failure to thrive, liver dysfunction, renal tubulopathy, muscle weakness and exercise intolerance. Belongs to the TTC19 family.
Protein type: Mitochondrial
Chromosomal Location of Human Ortholog: 17p12
Cellular Component: centrosome; midbody; mitochondrial inner membrane; mitochondrion
Molecular Function: protein binding
Biological Process: cytokinesis
Disease: Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Research Articles on TTC19
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Product Notes
The TTC19 ttc19 (Catalog #AAA9418138) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TTC19 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TTC19 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500-1:2000. Researchers should empirically determine the suitability of the TTC19 ttc19 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TTC19, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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