Rabbit anti-Human TTBK2 Polyclonal Antibody | anti-TTBK2 antibody

TTBK2 Antibody

Cat. Num. AAA151356

• Gene Names: TTBK2; TTBK; SCA11
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: TTBK2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: TTBK2; Polyclonal Antibody; TTBK2 Antibody; TTBK; SCA11; KIAA0847; Tau-tubulin kinase 2; tau tubulin kinase 2; anti-TTBK2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TTBK2 antibody is human specific. At least four isoforms of TTBK2 are known to exist; this antibody will detect only the two largest isoforms.
• Purity/Purification: TTBK2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1244

• Applicable Applications for anti-TTBK2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: TTBK2 antibody can be used for detection of TTBK2 by immunohistochemistry at 5 mug/mL.
• Conjugate: Unconjugated
• Immunogen: TTBK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human TTBK2.
• Buffer: TTBK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TTBK2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Immunohistochemistry (IHC)

(Immunohistochemistry of TTBK2 in human placenta tissue with TTBK2 antibody at 5 μg/mL.)

Related Product Information for anti-TTBK2 antibody

TTBK2 Antibody: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.

NCBI and Uniprot Product Information

• NCBI GI #: 47940064
• NCBI GeneID: 146057
• UniProt Accession #: Q6IQ55; O94932; Q6ZN52; Q8IVV1
• Molecular Weight: 54,037 Da
• NCBI Official Full Name: TTBK2 protein
• NCBI Official Synonym Full Names: tau tubulin kinase 2
• NCBI Official Symbol: TTBK2
• NCBI Official Synonym Symbols: TTBK; SCA11
• NCBI Protein Information: tau-tubulin kinase 2
• UniProt Protein Name: Tau-tubulin kinase 2
• Protein Family: Tau-tubulin kinase
• UniProt Gene Name: TTBK2
• UniProt Synonym Gene Names: KIAA0847
• UniProt Entry Name: TTBK2_HUMAN

NCBI Description

This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]

Uniprot Description

TTBK2: Serine/threonine kinase which is able to phosphorylate tau on serines. Defects in TTBK2 are the cause of spinocerebellar ataxia type 11 (SCA11). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA11 is an autosomal dominant cerebellar ataxia (ADCA). It is a relatively benign, late-onset, slowly progressive neurologic disorder. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CK1 group; TTBK family

Chromosomal Location of Human Ortholog: 15q15.2

Cellular Component: centriole; extracellular space; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: regulation of cell shape; peptidyl-serine phosphorylation; smoothened signaling pathway; organelle organization and biogenesis; cilium biogenesis

Disease: Spinocerebellar Ataxia 11