Rabbit anti-Human TTBK1 Polyclonal Antibody | anti-TTBK1 antibody

TTBK1, ID (TTBK1, BDTK, KIAA1855, Tau-tubulin kinase 1, Brain-derived tau kinase) (FITC)

Cat. Num. AAA6359807

• Gene Names: TTBK1; BDTK
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TTBK1; Polyclonal Antibody; ID (TTBK1; BDTK; KIAA1855; Tau-tubulin kinase 1; Brain-derived tau kinase) (FITC); Brain-derived tau kinase; anti-TTBK1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-TTBK1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TTBK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 667-695 amino acids from the Central region of human TTBK1.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TTBK1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the TTBK1 antibody detected the TTBK1 protein (arrow).)

Related Product Information for anti-TTBK1 antibody

Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.

Product Categories/Family for anti-TTBK1 antibody

Antibodies; Protein Kinases

References

Vazquez-Higuera, J.L., et al. Neurobiol. Aging (2010). In press: Sato, S., et al. J. Neurosci. 28(53):14511-14521(2008). Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007): Mungall, A.J., et al. Nature 425(6960):805-811(2003). Takahashi, M., et al. FEBS Lett. 372(1):59-64(1995).

NCBI and Uniprot Product Information

• NCBI GI #: 58761548
• NCBI GeneID: 84630
• NCBI Accession #: NP_115927.1
• NCBI GenBank Nucleotide #: NM_032538.1
• UniProt Accession #: Q5TCY1; Q2L6C6; Q6ZNH0; Q8N444; Q96JH2; A2A2U5
• Molecular Weight: 69,084 Da
• NCBI Official Full Name: tau-tubulin kinase 1
• NCBI Official Synonym Full Names: tau tubulin kinase 1
• NCBI Official Symbol: TTBK1
• NCBI Official Synonym Symbols: BDTK
• NCBI Protein Information: tau-tubulin kinase 1; brain-derived tau kinase
• UniProt Protein Name: Tau-tubulin kinase 1
• Protein Family: Tau-tubulin kinase
• UniProt Gene Name: TTBK1
• UniProt Synonym Gene Names: BDTK; KIAA1855
• UniProt Entry Name: TTBK1_HUMAN

Uniprot Description

TTBK1: Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, CK1; CK1 group; TTBK family

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; ATP binding

Biological Process: regulation of cell shape; peptidyl-serine phosphorylation; substantia nigra development