Rabbit anti-Human TSLP Polyclonal Antibody | anti-TSLP antibody

TSLP Rabbit Polyclonal

Cat. Num. AAA7605280

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TSLP; Polyclonal Antibody; TSLP Rabbit Polyclonal; anti-TSLP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 63

• Applicable Applications for anti-TSLP antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: Thymic stromal lymphopoietin
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemical of paraffin-embedded human kidney using MBS7605280 (TSLP antibody) at dilution of 1:50 )

NCBI and Uniprot Product Information

• NCBI GI #: 190886449
• NCBI GeneID: 85480
• NCBI Accession #: NP_612561.2
• NCBI GenBank Nucleotide #: NM_138551.4
• Molecular Weight: 7,426 Da
• NCBI Official Full Name: thymic stromal lymphopoietin isoform 2
• NCBI Official Synonym Full Names: thymic stromal lymphopoietin
• NCBI Official Symbol: TSLP
• NCBI Protein Information: thymic stromal lymphopoietin
• UniProt Protein Name: Thymic stromal lymphopoietin
• Protein Family: Thymic stromal lymphopoietin
• UniProt Gene Name: TSLP
• UniProt Entry Name: TSLP_HUMAN

NCBI Description

This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Description

TSLP: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q22.1

Cellular Component: extracellular space

Molecular Function: cytokine activity