Western Blot (WB)
(Western blot analysis of TSC1 with lysate from Jurkat cells.)
Rabbit TSC1 Polyclonal Antibody | anti-TSC1 antibody
TSC1 Antibody
Gene Names
TSC1; LAM; TSC
Applications
Western Blot
Purity
Affinity Chromatography
Synonyms
TSC1; Polyclonal Antibody; TSC1 Antibody; Rabbit Polyclonal TSC1 Antibody; Polyclonal TSC1 antibody; anti-TSC1 antibody; TSC1 antibody; MGC86987 antibody; TSC-1 antibody; TSC 1 antibody; TSC antibody; KIAA0243 antibody; TSC-1; LAM antibody; TSC 1
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Chromatography
Form/Format
Supplied in PBS buffer, pH 7.2, containing 30% Glycerol, 0.5% BSA, 5mM EDTA and 0.01% Thimerosal
Concentration
500 ug/ml (varies by lot)
Sequence Length
7
Applicable Applications for anti-TSC1 antibody
Western Blot (WB)
Application Notes
WB: 1-4 ug/ml
Immunogen
TSC1 antibody was raised in Rabbit using synthetic peptide surrounding amino acid 1075 of mouse TSC1 as the immunogen.
Cross-Reactivity
Human, Mouse, Rat
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of TSC1 with lysate from Jurkat cells.)
Western Blot (WB)
(Western blot analysis of TSC1 with lysate from Jurkat cells.)
Related Product Information for anti-TSC1 antibody
TBC1 is a 160 kDa Akt serine/threonine kinase substrate that plays a critical role in regulating insulin-stimulated exocytosis of glucose transporter GLUT4. Increased in insulin treatment stimulate phophorylation of AS160 that regulates GLUT4 translocation via inactivation of the Rab GTPase function.
Product Categories/Family for anti-TSC1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
TSC1, partial
NCBI Official Synonym Full Names
TSC complex subunit 1
NCBI Official Symbol
TSC1
NCBI Official Synonym Symbols
LAM; TSC
NCBI Protein Information
hamartin
Protein Family
NCBI Description
This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]
Research Articles on TSC1
Similar Products
Product Notes
The TSC1 (Catalog #AAA5311560) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TSC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1-4 ug/ml. Researchers should empirically determine the suitability of the TSC1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TSC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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