Western Blot (WB)
(Fig.1. Western Blot analysis of various cells using TrxR2 Polyclonal Antibody. Secondary antibody was diluted at 1:20000.)
Rabbit TrxR2 Polyclonal Antibody | anti-TrxR2 antibody
TrxR2 Polyclonal Antibody
IHC-P: 1:100-1:300
ELISA: 1:10000
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Western Blot (WB)
(Fig.1. Western Blot analysis of various cells using TrxR2 Polyclonal Antibody. Secondary antibody was diluted at 1:20000.)
Western Blot (WB)
(Fig.1. Western Blot analysis of various cells using TrxR2 Polyclonal Antibody. Secondary antibody was diluted at 1:20000.)
Western Blot (WB)
(Fig.2. Western Blot analysis of HT29 cells using TrxR2 Polyclonal Antibody. Secondary antibody was diluted at 1:20000.)
Western Blot (WB)
(Fig.2. Western Blot analysis of HT29 cells using TrxR2 Polyclonal Antibody. Secondary antibody was diluted at 1:20000.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging reactive oxygen species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms, including a few localized in the cytosol and some lacking the C-terminal Sec residue, have been found for this gene. [provided by RefSeq, Jun 2017]
Uniprot Description
TXNRD2: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - pyrimidine; EC 1.8.1.9; Nuclear receptor co-regulator; Oxidoreductase
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: mitochondrion; mitochondrial matrix
Molecular Function: protein binding; thioredoxin-disulfide reductase activity; mercury (II) reductase activity; FAD binding; mercury ion binding; NADP binding
Biological Process: response to reactive oxygen species; response to oxygen radical; cell redox homeostasis; detoxification of mercury ion
Research Articles on TrxR2
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Product Notes
The TrxR2 txnrd2 (Catalog #AAA9703314) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TrxR2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TrxR2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA). WB: 1:500-1:2000 IHC-P: 1:100-1:300 ELISA: 1:10000. Researchers should empirically determine the suitability of the TrxR2 txnrd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TrxR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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