Rabbit anti-Human TRPV3 Polyclonal Antibody | anti-TRPV3 antibody

TRPV3 Antibody

Cat. Num. AAA9404142

• Gene Names: TRPV3; OLMS; VRL3; FNEPPK2
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: TRPV3; Polyclonal Antibody; TRPV3 Antibody; OLMS; VRL3; anti-TRPV3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total TRPV3 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Concentration: 2.1 mg/ml (varies by lot)
• Sequence Length: 790

• Applicable Applications for anti-TRPV3 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to residues near the C terminal of human transient receptor potential cation channel, subfamily V, member 3
• Target Name: TRPV3
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/30.)

Related Product Information for anti-TRPV3 antibody

This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-TRPV3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 21735483
• NCBI GeneID: 162514
• NCBI Accession #: NP_659505.1
• NCBI GenBank Nucleotide #: NM_145068.3
• UniProt Accession #: Q8NET8; Q8NDW7; Q8NET9; Q8NFH2
• Molecular Weight: 87,661 Da
• NCBI Official Full Name: transient receptor potential cation channel subfamily V member 3 isoform 2
• NCBI Official Synonym Full Names: transient receptor potential cation channel, subfamily V, member 3
• NCBI Official Symbol: TRPV3
• NCBI Official Synonym Symbols: OLMS; VRL3; FNEPPK2
• NCBI Protein Information: transient receptor potential cation channel subfamily V member 3
• UniProt Protein Name: Transient receptor potential cation channel subfamily V member 3
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: TRPV3
• UniProt Synonym Gene Names: TrpV3; VRL-3
• UniProt Entry Name: TRPV3_HUMAN

NCBI Description

This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Description

TRPV3: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). May form a heteromeric channel with TRPV1. Interacts with TRPV1. Abundantly expressed in CNS. Widely expressed at low levels. Detected in dorsal root ganglion. Expressed in the keratinocyte layers of the outer root sheath and, to lesser extent, to the matrix of the hair follicles. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: plasma membrane; integral to membrane; receptor complex

Molecular Function: calcium channel activity

Biological Process: negative regulation of hair cycle; response to heat; transmembrane transport

Disease: Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques; Palmoplantar Keratoderma, Nonepidermolytic, Focal 2