Goat TRPC6 Polyclonal Antibody | anti-TRPC6 antibody
Goat anti-TRPC6 Antibody
Western Blot: Preliminary experiments gave an approx 80kDa band in Human Spleen and Testis lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 106kDa according to NP_004612.2. The 80kDa band was successfully blocked by incubation with the immunizing peptide.
Flow cytometry: This antibody has been proven to specifically react to TRPC6 in FC.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
Uniprot Description
TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q22.1
Cellular Component: cytoplasm; cytosol; integral to plasma membrane; membrane; plasma membrane
Molecular Function: actin binding; actinin binding; ATPase binding; calcium channel activity; clathrin binding; protein binding; store-operated calcium channel activity
Biological Process: aging; cation transport; cytosolic calcium ion homeostasis; elevation of cytosolic calcium ion concentration; manganese ion transport; negative regulation of dendrite morphogenesis; neuron differentiation; platelet activation; positive regulation of calcium ion transport; positive regulation of ion transmembrane transporter activity; positive regulation of neuron differentiation; single fertilization
Disease: Focal Segmental Glomerulosclerosis 2
Research Articles on TRPC6
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Product Notes
The TRPC6 trpc6 (Catalog #AAA421378) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-TRPC6 Antibody reacts with Tested: Mouse; Expected from sequence similarity: Human, Dog, Pig, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's TRPC6 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Flow Cytometry (FC/FACS). Peptide ELISA: Antibody detection limit dilution 1: 2000. Western Blot: Preliminary experiments gave an approx 80kDa band in Human Spleen and Testis lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 106kDa according to NP_004612.2. The 80kDa band was successfully blocked by incubation with the immunizing peptide. Flow cytometry: This antibody has been proven to specifically react to TRPC6 in FC. Researchers should empirically determine the suitability of the TRPC6 trpc6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: EKLSMEPNQE ETN. It is sometimes possible for the material contained within the vial of "TRPC6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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