Rabbit TRPC3 Polyclonal Antibody | anti-TRPC3 antibody

TRPC3 Antibody

Cat. Num. AAA9402515

• Gene Names: TRPC3; TRP3; SCA41
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: TRPC3; Polyclonal Antibody; TRPC3 Antibody; Short transient receptor potential channel 3; Htrp3; anti-TRPC3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 848

• Applicable Applications for anti-TRPC3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 14 amino acid peptide from near the carboxy terminus of human TRPC3.
• Target Name: TRPC3
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TRPC3 in human brain tissue lysate with TRPC3 antibody at (A) 1 and (B) 2 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of TRPC3 in mouse heart tissue with TRPC3 antibody at 2 ug/mL.)

Related Product Information for anti-TRPC3 antibody

The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP"(TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.

Product Categories/Family for anti-TRPC3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 2225937
• NCBI GeneID: 7222
• UniProt Accession #: Q13507; O00593; Q15660; Q52M35; Q5G1L5; A7VJS1; E9PCJ9
• Molecular Weight: 97,355 Da
• NCBI Official Full Name: transient receptor potential related channel 3 protein
• NCBI Official Synonym Full Names: transient receptor potential cation channel, subfamily C, member 3
• NCBI Official Symbol: TRPC3
• NCBI Official Synonym Symbols: TRP3; SCA41
• NCBI Protein Information: short transient receptor potential channel 3
• UniProt Protein Name: Short transient receptor potential channel 3
• Protein Family: Short transient receptor potential channel
• UniProt Gene Name: TRPC3
• UniProt Synonym Gene Names: TRP3; TrpC3; TRP-3; hTrp-3; hTrp3
• UniProt Entry Name: TRPC3_HUMAN

NCBI Description

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.