Western Blot (WB)
(Western blot analysis in 293 cell line lysates (35ug/lane) using MBS627259. This demonstrates that MBS627259 detected the TRKC protein (arrow).)
Rabbit anti-Human TrkC Polyclonal Antibody | anti-NTRK3 antibody
TrkC, NT (GP145-TrkC, NTRK3, NT-3 Growth Factor Receptor, Neurotrophic Tyrosine Kinase Receptor Type 3, TrkC Tyrosine Kinase)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Western Blot (WB)
(Western blot analysis in 293 cell line lysates (35ug/lane) using MBS627259. This demonstrates that MBS627259 detected the TRKC protein (arrow).)
Western Blot (WB)
(Western blot analysis in 293 cell line lysates (35ug/lane) using MBS627259. This demonstrates that MBS627259 detected the TRKC protein (arrow).)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis in formalin fixed and paraffin embedded human cancer tissue using MBS627259 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS627259 for immunohistochemistry.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis in formalin fixed and paraffin embedded human cancer tissue using MBS627259 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS627259 for immunohistochemistry.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Uniprot Description
TrkC: a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Trk family
Chromosomal Location of Human Ortholog: 15q25
Cellular Component: integral to plasma membrane; cytoplasm; receptor complex
Molecular Function: neurotrophin binding; protein binding; ephrin receptor binding; p53 binding; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding
Biological Process: circadian rhythm; mechanoreceptor differentiation; positive regulation of positive chemotaxis; peptidyl-tyrosine phosphorylation; activation of MAPK activity; activation of protein kinase B; protein amino acid autophosphorylation; positive regulation of axon extension involved in regeneration; neuron migration; positive regulation of peptidyl-serine phosphorylation; response to ethanol; negative regulation of protein amino acid phosphorylation; negative regulation of astrocyte differentiation; positive regulation of cell proliferation; modification by virus of host cell transcription; neuron fate specification; response to axon injury; transmembrane receptor protein tyrosine kinase signaling pathway; response to corticosterone stimulus; positive regulation of cell migration
Research Articles on NTRK3
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Product Notes
The NTRK3 ntrk3 (Catalog #AAA627259) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TrkC, NT (GP145-TrkC, NTRK3, NT-3 Growth Factor Receptor, Neurotrophic Tyrosine Kinase Receptor Type 3, TrkC Tyrosine Kinase) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TrkC can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500 Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the NTRK3 ntrk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TrkC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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