Western Blot (WB)
(Anti-TRIF antibody, MBS176036, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human TICAM1, 44.7KD(162aa tag+ Q468-E712)Lane 1: Recombinant Human TICAM1 Protein 10ngLane 2: Recombinant Human TICAM1 Protein 5ngLane 3: Recombinant Human TICAM1 Protein 2.5ngLane 4: Recombinant Human TICAM1 Protein 1.25ng )
Rabbit anti-Human TRIF Polyclonal Antibody | anti-TICAM1 antibody
Anti-TRIF antibody
Western Blot (WB)
(Anti-TRIF antibody, MBS176036, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human TICAM1, 44.7KD(162aa tag+ Q468-E712)Lane 1: Recombinant Human TICAM1 Protein 10ngLane 2: Recombinant Human TICAM1 Protein 5ngLane 3: Recombinant Human TICAM1 Protein 2.5ngLane 4: Recombinant Human TICAM1 Protein 1.25ng )
Western Blot (WB)
(Anti-TRIF antibody, MBS176036, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human TICAM1, 44.7KD(162aa tag+ Q468-E712)Lane 1: Recombinant Human TICAM1 Protein 10ngLane 2: Recombinant Human TICAM1 Protein 5ngLane 3: Recombinant Human TICAM1 Protein 2.5ngLane 4: Recombinant Human TICAM1 Protein 1.25ng )
Western Blot (WB)
(Anti-TRIF antibody, MBS176036, Western blottingLane 1: JURKAT Cell LysateLane 2: HL-60 Cell Lysate )
Western Blot (WB)
(Anti-TRIF antibody, MBS176036, Western blottingLane 1: JURKAT Cell LysateLane 2: HL-60 Cell Lysate )
Immunohistochemistry (IHC)
(Anti-TRIF antibody, MBS176036, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-TRIF antibody, MBS176036, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Background: TICAM(TIR DOMAIN-CONTAINING ADAPTOR MOLECULE 1), also known as TICAM1 or TRIF, is an adapter in responding to activation of toll-like receptors(TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. By genomic sequence analysis, Oshiumi et al.(2003) mapped the TICAM1 gene to chromosome 19p13.3. By coimmunoprecipitation analysis, Oshiumi et al.(2003) showed that TICAM1 interacts specifically with TLR3, but not with other TLRs. Functional analysis showed that the association of TLR3 and TICAM1 mediates dsRNA activation of IFNB, through either NFKB, AP1, or IRF3. TICAM1 activation of NFKB was found to occur predominantly through IRAK1 rather than IRAK2. Small interfering(si)RNA blockage of TICAM1, just upstream of the TIR domain, reduced IFNB production in response to dsRNA.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
Uniprot Description
TICAM1: an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1.
Protein type: Adaptor/scaffold; Apoptosis
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: endosome membrane; cytosol
Molecular Function: protein binding; signal transducer activity; protein kinase binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric oxide biosynthetic process; positive regulation of protein binding; MyD88-independent toll-like receptor signaling pathway; regulation of protein homodimerization activity; positive regulation of interleukin-6 production; toll-like receptor 3 signaling pathway; positive regulation of tumor necrosis factor production; positive regulation of natural killer cell activation; activation of NF-kappaB transcription factor; response to exogenous dsRNA; positive regulation of chemokine biosynthetic process; positive regulation of protein ubiquitination; macrophage activation during immune response; positive regulation of interferon-beta biosynthetic process; positive regulation of B cell proliferation; lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway; innate immune response; inflammatory response; toll-like receptor 4 signaling pathway; defense response to virus
Disease: Herpes Simplex Encephalitis, Susceptibility To, 4
Research Articles on TICAM1
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Product Notes
The TICAM1 ticam1 (Catalog #AAA176036) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-TRIF antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TRIF can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin. Researchers should empirically determine the suitability of the TICAM1 ticam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRIF, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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