Western Blot (WB)
(TRAPPC2 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TRAPPC2 antibody detected the TRAPPC2 protein (arrow).)
Rabbit TRAPPC2 Polyclonal Antibody | anti-TRAPPC2 antibody
TRAPPC2 Antibody (N-term)
Western Blot (WB)
(TRAPPC2 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TRAPPC2 antibody detected the TRAPPC2 protein (arrow).)
Western Blot (WB)
(TRAPPC2 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TRAPPC2 antibody detected the TRAPPC2 protein (arrow).)
a large multi-subunit complex involved in the targeting and fusion
of endoplasmic reticulum-to-Golgi transport vesicles with their
acceptor compartment. In addition, the encoded protein can bind
c-myc promoter-binding protein 1 and block its transcriptional
repression capability. Mutations in this gene are a cause of
spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene
of this gene is located on chromosome 19, and other pseudogenes are
found on chromosomes 8 and Y.
Jeyabalan, J., et al. PLoS ONE 5 (5), E10646 (2010) :
Xia, X.Y., et al. Clin. Chim. Acta 410 (1-2), 39-42 (2009) :
Guo, H., et al. J. Genet. 88(1):87-91(2009)
Xiong, F., et al. Eur. J. Hum. Genet. 17(4):510-516(2009)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Description
TRAPPC2: Prevents MBP1-mediated transcriptional repression and antagonizes MBP1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi. Belongs to the TRAPP small subunits family. Sedlin subfamily. Part of the multisubunit TRAPP (transport protein particle) complex. Interacts with MBP1 and TRAPPC2L. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; endoplasmic reticulum; nucleus
Molecular Function: protein binding; transcription factor binding
Biological Process: ER to Golgi vesicle-mediated transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; skeletal development
Disease: Spondyloepiphyseal Dysplasia Tarda, X-linked
Research Articles on TRAPPC2
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Product Notes
The TRAPPC2 trappc2 (Catalog #AAA9207911) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 11-39. The TRAPPC2 Antibody (N-term) reacts with Human (Predicted Reactivity: Bovine, Chicken, Zebrafish, Mouse, Pig) and may cross-react with other species as described in the data sheet. AAA Biotech's TRAPPC2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the TRAPPC2 trappc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRAPPC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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