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Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human placenta using at dilution of 1:20.)

Rabbit anti-Human Transforming protein RhoA Polyclonal Antibody | anti-RHOA antibody

Transforming protein RhoA Polyclonal Antibody

Gene Names
RHOA; ARHA; ARH12; RHO12; RHOH12
Reactivity
Human
Applications
Immunohistochemistry
Purity
Caprylic Acid Ammonium Sulfate Precipitation purified
Synonyms
Transforming protein RhoA; Polyclonal Antibody; Transforming protein RhoA Polyclonal Antibody; ARH12; ARHA; RHO12; RHOA; h12; Rho cDNA clone 12; anti-RHOA antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous level of total Transforming protein RhoA polyclonal antibody.
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation purified
Form/Format
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
193
Applicable Applications for anti-RHOA antibody
Immunohistochemistry (IHC)
Application Notes
Immunohistochemistry: 1:20 - 1:200
Immunogen
Recombinant Human Transforming protein RhoA protein
Immunogen Type
Protein
Preparation and Storage
Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human placenta using at dilution of 1:20.)

Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human placenta using at dilution of 1:20.)
Related Product Information for anti-RHOA antibody
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity.May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex.
Product Categories/Family for anti-RHOA antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
387
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
21,768 Da
NCBI Official Full Name
transforming protein RhoA isoform 1
NCBI Official Synonym Full Names
ras homolog family member A
NCBI Official Symbol
RHOA
NCBI Official Synonym Symbols
ARHA; ARH12; RHO12; RHOH12
NCBI Protein Information
transforming protein RhoA
UniProt Protein Name
Transforming protein RhoA
Protein Family
UniProt Gene Name
RHOA
UniProt Synonym Gene Names
ARH12; ARHA; RHO12; h12
UniProt Entry Name
RHOA_HUMAN

Uniprot Description

RHOA: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: apical junction complex; cell cortex; cell junction; cleavage furrow; cytosol; endoplasmic reticulum membrane; endosome; extrinsic to internal side of plasma membrane; focal adhesion; lamellipodium; plasma membrane; vesicle

Molecular Function: GTP binding; GTPase activity; myosin binding; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; actin cytoskeleton reorganization; apical junction assembly; cell migration; endothelial cell migration; ephrin receptor signaling pathway; negative chemotaxis; negative regulation of axonogenesis; phosphoinositide-mediated signaling; platelet activation; positive regulation of axonogenesis; positive regulation of cytokinesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of lipase activity; positive regulation of neuron differentiation; positive regulation of stress fiber formation; regulation of actin cytoskeleton organization and biogenesis; regulation of cell migration; regulation of osteoblast proliferation; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; stress fiber formation; substantia nigra development; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway

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Product Notes

The RHOA rhoa (Catalog #AAA9416206) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Transforming protein RhoA Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Transforming protein RhoA can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:20 - 1:200. Researchers should empirically determine the suitability of the RHOA rhoa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Transforming protein RhoA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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