Western Blot (WB)
(Western Blot: Sample: Recombinant TGFb2, Human.)
Rabbit anti-Human Transforming Growth Factor Beta 2 Polyclonal Antibody | anti-TGFb2 antibody
Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- SGKTPHLL LMLLPSYRLE SQQTNRRKKR ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY
Immunohistochemistry: 5-20ug/mL;1:10-50
Immunocytochemistry: 5-20ug/mL;1:10-50
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant TGFb2, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant TGFb2, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Lung Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Lung Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Stomach Cancer Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Stomach Cancer Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Stomach Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Stomach Tissue.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Uniprot Description
TGFB2: TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth. Homodimer; disulfide-linked. Heterodimers with TGFB1 and with TGFB3 have been found in bone. Interacts with the serine proteases, HTRA1 and HTRA3. Interacts with ASPN. Belongs to the TGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: axon; cell soma; extracellular matrix; extracellular region; extracellular space
Molecular Function: amyloid-beta binding; cytokine activity; growth factor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor binding; transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding
Biological Process: activation of protein kinase activity; angiogenesis; BMP signaling pathway; cardiac muscle cell proliferation; cardioblast differentiation; catagen; cell cycle arrest; cell death; cell development; cell growth; cell migration; cell morphogenesis; cell proliferation; cell-cell junction organization; cell-cell signaling; collagen fibril organization; dopamine biosynthetic process; embryonic development; embryonic gut development; embryonic limb morphogenesis; epithelial to mesenchymal transition; eye development; generation of neurons; glial cell migration; hair follicle development; hair follicle morphogenesis; heart development; heart morphogenesis; hemopoiesis; inner ear development; kidney development; male gonad development; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of immune response; negative regulation of Ras protein signal transduction; neural tube closure; neuron development; neutrophil chemotaxis; odontogenesis; palate development; platelet degranulation; positive regulation of cardioblast differentiation; positive regulation of catagen; positive regulation of cell adhesion mediated by integrin; positive regulation of cell cycle; positive regulation of cell division; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of heart contraction; positive regulation of immune response; positive regulation of integrin biosynthetic process; positive regulation of neuron apoptotic process; positive regulation of ossification; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein secretion; positive regulation of stress-activated MAPK cascade; protein amino acid phosphorylation; regulation of transforming growth factor-beta2 production; response to drug; response to hypoxia; response to progesterone; response to wounding; salivary gland morphogenesis; skeletal system development; SMAD protein import into nucleus; somatic stem cell division; transforming growth factor beta receptor signaling pathway; uterine wall breakdown; uterus development; wound healing
Disease: Loeys-dietz Syndrome 4
Research Articles on TGFb2
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Product Notes
The TGFb2 tgfb2 (Catalog #AAA2026710) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Transforming Growth Factor Beta 2 (TGFb2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Transforming Growth Factor Beta 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-2ug/mL;1:100-500 Immunohistochemistry: 5-20ug/mL;1:10-50 Immunocytochemistry: 5-20ug/mL;1:10-50 Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the TGFb2 tgfb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- SGKTPHLL LMLLPSYRLE SQQTNRRKKR ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY. It is sometimes possible for the material contained within the vial of "Transforming Growth Factor Beta 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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