Rabbit Transferrin Polyclonal Antibody | anti-TF antibody

Transferrin

Cat. Num. AAA592322

• Gene Names: TF; TFQTL1; PRO1557; PRO2086
• Reactivity: Human. Others not tested
• Applications: Western Blot, ELISA
• Purity: Purified
• Synonyms: Transferrin; Polyclonal Antibody; Rabbit anti-human transferrin polyclonal antibody; purified with a Protein G affinity column; anti-TF antibody

• Host: Rabbit
• Reactivity: Human. Others not tested
• Clonality: Polyclonal
• Specificity: This antibody recognizes human transferrin.; Transferrin
• Purity/Purification: Purified
• Form/Format: Lyophilized from a solution of 0.01M PBS, pH7.4
• Sequence Length: 698

• Applicable Applications for anti-TF antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Suggested application and working condition:; Western blot: 1:50000 (Antigen: 1.5 mug/Lane); ELISA: 150,000~1:300,000 dilution (Coating antigen: 800 ng/well).
• Target Protein: Transferrin
• Immunogen: Human transferrin, partially iron saturated
• Research Area: Biochemistry
• Preparation and Storage: Store at -20 degree C. Avoid repeated freeze/thaw cycles.

Testing Data

Related Product Information for anti-TF antibody

Rabbit anti-human transferrin polyclonal antibody, purified with a Protein G affinity column

Product Categories/Family for anti-TF antibody

Primary Antibodies; Polyclonal Antibodies to Human Plasma Protein

NCBI and Uniprot Product Information

• NCBI GI #: 248648
• NCBI GeneID: 7018
• Molecular Weight: 77,064 Da
• NCBI Official Full Name: transferrin
• NCBI Official Synonym Full Names: transferrin
• NCBI Official Symbol: TF
• NCBI Official Synonym Symbols: TFQTL1; PRO1557; PRO2086
• NCBI Protein Information: serotransferrin; beta-1 metal-binding globulin; siderophilin
• UniProt Protein Name: Serotransferrin
• Protein Family: Transferrin
• UniProt Gene Name: TF
• UniProt Entry Name: TRFE_HUMAN

NCBI Description

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Uniprot Description

TF: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Defects in TF are the cause of atransferrinemia (ATRAF). Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Belongs to the transferrin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: extracellular space; cell surface; early endosome; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; perinuclear region of cytoplasm; endocytic vesicle; apical plasma membrane; late endosome; basal plasma membrane; endosome membrane; vesicle

Molecular Function: protein binding; ferric iron binding; ubiquitin protein ligase binding

Biological Process: retinal homeostasis; platelet activation; platelet degranulation; cellular iron ion homeostasis; transferrin transport; blood coagulation; transmembrane transport

Disease: Atransferrinemia