Transferrin Native Protein | TF native protein

Bovine Transferrin

Cat. Num. AAA717013

• Gene Names: TF; TFQTL1; PRO1557; PRO2086
• Applications: ELISA, Western Blot
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transferrin; Bovine Transferrin; Serotransferrin; Beta-1 metal-binding globulin; Siderophilin; TF native protein

• Host: Purified from Bovine Serum
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid

• Applicable Applications for TF native protein: ELISA (EIA), Western Blot (WB)
• Peptide: Full length native Bovine Transferrin
• Storage Buffer: PBS,pH7.4 ,50%glycerol
• Preparation and Storage: Aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.

SDS-PAGE

Related Product Information for TF native protein

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

NCBI and Uniprot Product Information

• NCBI GI #: 248648
• NCBI GeneID: 7018
• UniProt Accession #: P02787; O43890; Q1HBA5; Q9NQB8; Q9UHV0
• Molecular Weight: 77,064 Da
• NCBI Official Full Name: transferrin
• NCBI Official Synonym Full Names: transferrin
• NCBI Official Symbol: TF
• NCBI Official Synonym Symbols: TFQTL1; PRO1557; PRO2086
• NCBI Protein Information: serotransferrin; siderophilin; beta-1 metal-binding globulin
• UniProt Protein Name: Serotransferrin
• Protein Family: Transferrin
• UniProt Gene Name: TF
• UniProt Synonym Gene Names: Transferrin
• UniProt Entry Name: TRFE_HUMAN

NCBI Description

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

Uniprot Description

Function: Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Subunit structure: Monomer.

Subcellular location: Secreted.

Tissue specificity: Expressed by the liver and secreted in plasma.

Polymorphism: Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1).

Involvement in disease: Defects in TF are the cause of atransferrinemia (ATRAF) [

MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia. Ref.4 Ref.39

Sequence similarities: Belongs to the transferrin family.Contains 2 transferrin-like domains.

Sequence caution: The sequence AAF22007.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.