Rabbit anti-Human TRAF3IP2 Polyclonal Antibody | anti-TRAF3IP2 antibody

TRAF3IP2, CT (TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6, Adapter protein CIKS, Connection to IKK and SAPK/JNK, Nuclear factor NF-kappa-B activator 1, TRAF3-interacting protein 2) (MaxLight 490)

Cat. Num. AAA6357874

• Gene Names: TRAF3IP2; ACT1; CIKS; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; PSORS13
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TRAF3IP2; Polyclonal Antibody; CT (TRAF3IP2; C6orf2; C6orf4; C6orf5; C6orf6; Adapter protein CIKS; Connection to IKK and SAPK/JNK; Nuclear factor NF-kappa-B activator 1; TRAF3-interacting protein 2) (MaxLight 490); TRAF3-interacting protein 2; anti-TRAF3IP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-TRAF3IP2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TRAF3IP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-483 amino acids from the C-terminal region of human TRAF3IP2.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-TRAF3IP2 antibody

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene.

Product Categories/Family for anti-TRAF3IP2 antibody

Antibodies; Adapter Proteins

References

Ellinghaus, E., et al. Nat. Genet. 42(11):991-995(2010). Giltiay, N.V., et al. J. Immunol. 185(1):99-109(2010). Liu, C., et al. Sci Signal 2 (92), RA63 (2009): Li, X. Cytokine 41(2):105-113(2008). Huang, F., et al. J. Immunol. 179(10):6504-6513(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 256017207
• NCBI GeneID: 10758
• NCBI Accession #: NP_679211.2
• NCBI GenBank Nucleotide #: NM_147686.4
• UniProt Accession #: O43734; Q5R3A3; Q7Z6Q1; Q7Z6Q2; Q7Z6Q3; Q9H5W2; Q9H6Y3; Q9NS14; Q9UG72; B2RAY9; E1P555
• Molecular Weight: 63,585 Da
• NCBI Official Full Name: adapter protein CIKS isoform 2
• NCBI Official Synonym Full Names: TRAF3 interacting protein 2
• NCBI Official Symbol: TRAF3IP2
• NCBI Official Synonym Symbols: ACT1; CIKS; C6orf2; C6orf4; C6orf5; C6orf6; CANDF8; PSORS13
• NCBI Protein Information: adapter protein CIKS
• UniProt Protein Name: Adapter protein CIKS
• Protein Family: Adapter protein
• UniProt Gene Name: TRAF3IP2
• UniProt Synonym Gene Names: C6orf2; C6orf4; C6orf5; C6orf6; ACT1
• UniProt Entry Name: CIKS_HUMAN

NCBI Description

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq, Aug 2009]

Uniprot Description

TRAF3IP2: Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK. Defects in TRAF3IP2 are the cause of susceptibility to psoriasis type 13 (PSORS13). PSORS13 is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 6q21

Molecular Function: protein binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; immunoglobulin secretion; B cell apoptosis; humoral immune response

Disease: Candidiasis, Familial, 8; Psoriasis 13, Susceptibility To