Rabbit anti-Human, Mouse TRADD Polyclonal Antibody | anti-TRADD antibody

TRADD Antibody

Cat. Num. AAA9504771

• Gene Names: TRADD; Hs.89862
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Synonyms: TRADD; Polyclonal Antibody; TRADD Antibody; anti-TRADD antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: TRADD Antibody detects endogenous levels of total TRADD protein.
• Purity/Purification: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 252

• Applicable Applications for anti-TRADD antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; IHC: 1:50~1:100; ELISA: 1:5000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from human TRADD.
• Immunogen Range: 251-300
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TRADD Antibody. The picture on the right is blocked with the synthesized peptide.)

Western Blot (WB)

(Western blot analysis of lysates from COS7 cells, using TRADD Antibody. The lane on the right is blocked with the synthesized peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 1021311897
• NCBI GeneID: 8717
• NCBI Accession #: NP_001310481.1
• NCBI GenBank Nucleotide #: NM_001323552.1
• UniProt Accession #: Q15628; Q52NZ1; B2RDS3; B3KQZ9
• Molecular Weight: 34 kDa
• NCBI Official Full Name: tumor necrosis factor receptor type 1-associated DEATH domain protein
• NCBI Official Synonym Full Names: TNFRSF1A associated via death domain
• NCBI Official Symbol: TRADD
• NCBI Official Synonym Symbols: Hs.89862
• NCBI Protein Information: tumor necrosis factor receptor type 1-associated DEATH domain protein
• UniProt Protein Name: Tumor necrosis factor receptor type 1-associated DEATH domain protein
• Protein Family: Tumor necrosis factor receptor type 1-associated DEATH domain protein
• UniProt Gene Name: TRADD
• UniProt Synonym Gene Names: TNFR1-associated DEATH domain protein

NCBI Description

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.