Rabbit anti-Human, Mouse TRADD Polyclonal Antibody | anti-TRADD antibody

TRADD Rabbit Polyclonal

Cat. Num. AAA7605148

• Gene Names: TRADD; Hs.89862
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: TRADD; Polyclonal Antibody; TRADD Rabbit Polyclonal; anti-TRADD antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 312

• Applicable Applications for anti-TRADD antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: TNFRSF1A-associated via death domain
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat liver tissue slide using MBS7605148 (TRADD antibody at dilution of 1:200)

Western Blot (WB)

(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7605148 (TRADD Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 13378137
• NCBI GeneID: 8717
• NCBI Accession #: NP_003780.1
• NCBI GenBank Nucleotide #: NM_003789.3
• Molecular Weight: 27,904 Da
• NCBI Official Full Name: tumor necrosis factor receptor type 1-associated DEATH domain protein
• NCBI Official Synonym Full Names: TNFRSF1A associated via death domain
• NCBI Official Symbol: TRADD
• NCBI Official Synonym Symbols: Hs.89862
• NCBI Protein Information: tumor necrosis factor receptor type 1-associated DEATH domain protein
• UniProt Protein Name: Tumor necrosis factor receptor type 1-associated DEATH domain protein
• Protein Family: Tumor necrosis factor receptor type 1-associated DEATH domain protein
• UniProt Gene Name: TRADD
• UniProt Synonym Gene Names: TNFR1-associated DEATH domain protein
• UniProt Entry Name: TRADD_HUMAN

NCBI Description

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

TRADD: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. Found in all examined tissues.

Protein type: Apoptosis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16q22

Cellular Component: cytoplasm; cytoskeleton; cytosol; lipid raft; nucleus; plasma membrane; receptor complex

Molecular Function: identical protein binding; kinase binding; molecular adaptor activity; protein binding; protein complex binding; signal transducer activity; tumor necrosis factor receptor binding

Biological Process: activation of NF-kappaB transcription factor; apoptosis; caspase activation; I-kappaB kinase/NF-kappaB cascade; induction of apoptosis via death domain receptors; positive regulation of apoptosis; positive regulation of hair follicle development; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein heterooligomerization; signal transduction; tumor necrosis factor-mediated signaling pathway