Western Blot (WB)
(TPSAB1 Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the TPSAB1 antibody detected the TPSAB1 protein (arrow).)
Rabbit TPSAB1 Polyclonal Antibody | anti-TPSAB1 antibody
TPSAB1 Antibody (C-term)
Western Blot (WB)
(TPSAB1 Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the TPSAB1 antibody detected the TPSAB1 protein (arrow).)
Western Blot (WB)
(TPSAB1 Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the TPSAB1 antibody detected the TPSAB1 protein (arrow).)
proteases, the peptidase family S1. Tryptases are enzymatically
active only as heparin-stabilized tetramers, and they are resistant
to all known endogenous proteinase inhibitors. Several tryptase
genes are clustered on chromosome 16p13.3. These genes are
characterized by several distinct features. They have a highly
conserved 3' UTR and contain tandem repeat sequences at the 5'
flank and 3' UTR which are thought to play a role in regulation of
the mRNA stability. These genes have an intron immediately upstream
of the initiator Met codon, which separates the site of
transcription initiation from protein coding sequence. This feature
is characteristic of tryptases but is unusual in other genes. The
alleles of this gene exhibit an unusual amount of sequence
variation, such that the alleles were once thought to represent two
separate genes, alpha and beta 1. Beta tryptases appear to be the
main isoenzymes expressed in mast cells; whereas in basophils,
alpha tryptases predominate. Tryptases have been implicated as
mediators in the pathogenesis of asthma and other allergic and
inflammatory disorders.
Trivedi, N.N., et al. J. Allergy Clin. Immunol. 124(5):1099-1105(2009)
Radhakrishnan, Y., et al. Biol. Reprod. 81(4):647-656(2009)
Schiemann, F., et al. J. Immunol. 183(4):2223-2231(2009)
Wei, Z.Y., et al. Fa Yi Xue Za Zhi 25(3):164-167(2009)
NCBI and Uniprot Product Information
NCBI Description
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
Uniprot Description
TPSAB1: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Belongs to the peptidase S1 family. Tryptase subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Protease; Secreted; EC 3.4.21.59
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: extracellular matrix; extracellular space; extracellular region
Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity
Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response; proteolysis
Research Articles on TPSAB1
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Product Notes
The TPSAB1 tpsab1 (Catalog #AAA9212857) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 249-275. The TPSAB1 Antibody (C-term) reacts with Mouse (Predicted Reactivity: Human) and may cross-react with other species as described in the data sheet. AAA Biotech's TPSAB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the TPSAB1 tpsab1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TPSAB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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