Rabbit anti-Human, Mouse TPP1 Polyclonal Antibody | anti-TPP1 antibody

TPP1 Polyclonal Antibody

Cat. Num. AAA3011215

• Gene Names: TPP1; CLN2; GIG1; LPIC; SCAR7; TPP-1
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TPP1; Polyclonal Antibody; TPP1 Polyclonal Antibody; Cell growth inhibiting gene 1 protein; Cell growth-inhibiting gene 1 protein; Ceroid lipofuscinosis neuronal 2; Ceroid lipofuscinosis neuronal 2 late infantile (Jansky Bielschowsky disease); Ceroid lipofuscinosis neuronal 2 late infantile; CLN 2; CLN2; GIG 1; GIG1; Growth inhibiting protein 1; LPIC; Lysosomal pepstatin insensitive protease; Lysosomal pepstatin-insensitive protease; MGC21297; TPP 1; TPP I; TPP-1; TPP-I; Tpp1; TPP1_HUMAN; TPPI; Tripeptidyl aminopeptidase; Tripeptidyl peptidase I; Tripeptidyl-peptidase 1; Tripeptidyl-peptidase I; anti-TPP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TPP1 polyclonal antibody detects endogenous levels of TPP1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 563

• Applicable Applications for anti-TPP1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant full length Human TPP1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of TPP1 polyclonal antibody)

Related Product Information for anti-TPP1 antibody

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

NCBI and Uniprot Product Information

• NCBI GI #: 15928808
• NCBI GeneID: 1200
• UniProt Accession #: O14773
• Molecular Weight: ~ 50kDa
• NCBI Official Full Name: Tripeptidyl peptidase I
• NCBI Official Synonym Full Names: tripeptidyl peptidase 1
• NCBI Official Symbol: TPP1
• NCBI Official Synonym Symbols: CLN2; GIG1; LPIC; SCAR7; TPP-1
• NCBI Protein Information: tripeptidyl-peptidase 1
• UniProt Protein Name: Tripeptidyl-peptidase 1
• Protein Family: Tripeptidyl-peptidase
• UniProt Gene Name: TPP1
• UniProt Synonym Gene Names: CLN2; TPP-1; LPIC; TPP-I

NCBI Description

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]

Uniprot Description

Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus ().