Immunohistochemistry (IHC)
(Human Prostate (formalin-fixed, paraffin-embedded) stained with TPI1 antibody at 5ug/ml followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Goat anti-Human TPI1 Polyclonal Antibody | anti-TPI1 antibody
TPI1, CT (Triosephosphate Isomerase, TIM, Triose-phosphate Isomerase, TPI)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: ELISA: 1:16,000
Western Blot: 0.01-0.03ug/ml
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml
Immunohistochemistry (IHC)
(Human Prostate (formalin-fixed, paraffin-embedded) stained with TPI1 antibody at 5ug/ml followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Immunohistochemistry (IHC)
(Human Prostate (formalin-fixed, paraffin-embedded) stained with TPI1 antibody at 5ug/ml followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Western Blot (WB)
(Antibody staining (0.003ug/ml) of human liver lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
Western Blot (WB)
(Antibody staining (0.003ug/ml) of human liver lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Description
Catalytic activity: D-glyceraldehyde 3-phosphate = glycerone phosphate.
Pathway: Carbohydrate biosynthesis; gluconeogenesis.Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Subunit structure: Homodimer. Ref.27 Ref.29
Post-translational modification: The initiator methionine for isoform 2 is removed.
Involvement in disease: Triosephosphate isomerase deficiency (TPI deficiency) [MIM:190450]: Autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.Note: The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarities: Belongs to the triosephosphate isomerase family.
Sequence caution: The sequence AAB51316.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB59511.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH07086.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH07812.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH09329.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH11611.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH15100.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH17917.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH70129.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH70129.1 differs from that shown. Reason: Sequence differs at the C-terminus.The sequence AAN86636.1 differs from that shown. Reason: Frameshift at position 23. The sequence BAG36090.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA49379.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
Research Articles on TPI1
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Product Notes
The TPI1 tpi1 (Catalog #AAA648314) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The TPI1, CT (Triosephosphate Isomerase, TIM, Triose-phosphate Isomerase, TPI) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TPI1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot and Immunohistochemistry. Dilution: ELISA: 1:16,000 Western Blot: 0.01-0.03ug/ml Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml. Researchers should empirically determine the suitability of the TPI1 tpi1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TPI1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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