Rabbit TP53INP2 Polyclonal Antibody | anti-TP53INP2 antibody
TP53INP2 Antibody
Gene Names
TP53INP2; DOR; PINH; FLJ21759; FLJ23500; C20orf110; dJ1181N3.1; DKFZp434B2411; DKFZp434O0827
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
TP53INP2; Polyclonal Antibody; TP53INP2 Antibody; C20orf110; Diabetes and obesity regulated; p53 inducible protein U; DOR; p53-inducible protein U; PIG-U; PINH; T53I2_HUMAN; Tp53inp2; Tumor protein p53-inducible nuclear protein 2; anti-TP53INP2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
TP53INP2 Antibody detects endogenous levels of total TP53INP2.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-TP53INP2 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Similarity
The LC3 interacting region (LIR) motif mediates interaction with GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B and MAP1LC3C.
Subunit Structure
Interacts with VMP1, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, MAP1LC3C and THRA.
Function
Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
Note
huttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-TP53INP2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
23,980 Da
NCBI Official Full Name
tumor protein p53-inducible nuclear protein 2
NCBI Official Synonym Full Names
tumor protein p53 inducible nuclear protein 2
NCBI Official Symbol
TP53INP2
NCBI Official Synonym Symbols
DOR; PINH; FLJ21759; FLJ23500; C20orf110; dJ1181N3.1; DKFZp434B2411; DKFZp434O0827
NCBI Protein Information
tumor protein p53-inducible nuclear protein 2; PIG-U; OTTHUMP00000030701; OTTHUMP00000030703; p53-inducible protein U; diabetes and obesity regulated
UniProt Protein Name
Tumor protein p53-inducible nuclear protein 2
Protein Family
UniProt Gene Name
TP53INP2
UniProt Synonym Gene Names
C20orf110; PINH
UniProt Entry Name
T53I2_HUMAN
Uniprot Description
TP53INP2: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: PML body; autophagic vacuole; cytoplasmic vesicle; cytosol; nucleus
Molecular Function: protein binding
Biological Process: osteoblast differentiation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of autophagy; autophagic vacuole formation
Research Articles on TP53INP2
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Product Notes
The TP53INP2 tp53inp2 (Catalog #AAA9629601) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TP53INP2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TP53INP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the TP53INP2 tp53inp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TP53INP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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