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Western Blot (WB) (Western blot analysis of TP1 in human kidney tissue lysate with TP1 antibody at (A) 0.5 and (B) 1 μg/mL. )

Rabbit TP1 Polyclonal Antibody | anti-TEP1 antibody

TP1 Antibody

Gene Names
TEP1; TP1; TLP1; p240; TROVE1; VAULT2
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
TP1 Antibody is affinity chromatography purified via peptide column.
Synonyms
TP1; Polyclonal Antibody; TP1 Antibody; TLP1; p240; TROVE1; VAULT2; Telomerase protein component 1; Telomerase-associated protein 1; Telomerase protein 1; telomerase-associated protein 1; anti-TEP1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
TP1 Antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Sequence Length
2627
Applicable Applications for anti-TEP1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
TP1 antibody can be used for detection of TP1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
TP1 antibody was raised against a 20 amino acid synthetic peptide from near the amino terminus of human TP1.
Buffer
TP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
TP1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TP1 in human kidney tissue lysate with TP1 antibody at (A) 0.5 and (B) 1 μg/mL. )

Western Blot (WB) (Western blot analysis of TP1 in human kidney tissue lysate with TP1 antibody at (A) 0.5 and (B) 1 μg/mL. )

Immunohistochemistry (IHC)

(Immunohistochemical staining of human lung tissue using TP1 antibody at 2.5 μg/mL.)

Immunohistochemistry (IHC) (Immunohistochemical staining of human lung tissue using TP1 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of TP-1 in Human Lung cells with TP-1 antibody at 20 μg/mL.)

Immunofluorescence (IF) (Immunofluorescence of TP-1 in Human Lung cells with TP-1 antibody at 20 μg/mL.)
Related Product Information for anti-TEP1 antibody
TP1 Antibody: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
289,578 Da
NCBI Official Full Name
telomerase-associated protein TP-1
NCBI Official Synonym Full Names
telomerase-associated protein 1
NCBI Official Symbol
TEP1
NCBI Official Synonym Symbols
TP1; TLP1; p240; TROVE1; VAULT2
NCBI Protein Information
telomerase protein component 1; telomerase protein 1; p80 telomerase homolog; TROVE domain family, member 1
UniProt Protein Name
Telomerase protein component 1
UniProt Gene Name
TEP1
UniProt Synonym Gene Names
TLP1; TP1; Telomerase protein 1
UniProt Entry Name
TEP1_HUMAN

NCBI Description

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. [provided by RefSeq, Jul 2008]

Uniprot Description

TEP1: Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: chromosome, telomeric region; nuclear matrix; telomerase holoenzyme complex; cytoplasm; ribonucleoprotein complex

Molecular Function: telomerase activity; RNA binding; ATP binding

Biological Process: RNA-dependent DNA replication; telomere maintenance via recombination

Research Articles on TEP1

Similar Products

Product Notes

The TEP1 tep1 (Catalog #AAA150989) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TP1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). TP1 antibody can be used for detection of TP1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the TEP1 tep1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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