Western Blot (WB)
(Western blot analysis of TOPRS expression in HEK293 cells,The lane on the left is treated with the antigen-specific peptide.)
Rabbit anti-Human, Mouse TOPRS Polyclonal Antibody | anti-TOPRS antibody
TOPRS Antibody
Western Blot (WB)
(Western blot analysis of TOPRS expression in HEK293 cells,The lane on the left is treated with the antigen-specific peptide.)
Western Blot (WB)
(Western blot analysis of TOPRS expression in HEK293 cells,The lane on the left is treated with the antigen-specific peptide.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]
Uniprot Description
TOPORS: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation. Interacts with PARK7/DJ-1. Interacts with TOP1. Interacts with p53/TP53; can both ubiquitinate and sumoylate p53/TP53. Interacts with the SUMO1 conjugating enzyme UBE2I. Interacts with SUMO1. Interacts with NKX3-1; polyubiquitinates NKX3-1 and induces its proteasomal degradation. Interacts with SIN3A; sumoylates SIN3A. Interacts with IKBKE; induced by DNA damage. By genotoxic agents such as cisplatin and camptothecin. Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 9p21
Cellular Component: centriole; cytoplasmic dynein complex; gamma-tubulin complex; midbody; nuclear speck; nucleus; photoreceptor connecting cilium; PML body; spindle pole; ubiquitin ligase complex
Molecular Function: antigen binding; DNA binding; protein binding; SUMO ligase activity; ubiquitin-protein ligase activity
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; maintenance of protein localization in nucleus; negative regulation of apoptosis; positive regulation of ubiquitin-protein ligase activity; proteasomal ubiquitin-dependent protein catabolic process; protein monoubiquitination; protein polyubiquitination; protein sumoylation; response to DNA damage stimulus; retinal cone cell development; retinal rod cell development; ubiquitin-dependent protein catabolic process
Disease: Retinitis Pigmentosa 31
Research Articles on TOPRS
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Product Notes
The TOPRS topors (Catalog #AAA9418182) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TOPRS Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TOPRS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:500-1:2000. Researchers should empirically determine the suitability of the TOPRS topors for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TOPRS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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