Rabbit TOM70 Polyclonal Antibody | anti-TOM70 antibody

TOM70 Antibody

Cat. Num. AAA9412068

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: TOM70; Polyclonal Antibody; TOM70 Antibody; Translocase of the mitochondrial outer membrane 70; TOMM70A; anti-TOM70 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 608

• Applicable Applications for anti-TOM70 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 17 amino acid peptide near the amino terminus of human TOM70.
• Target Name: TOM70
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TOM70 in 293 cell lysate with TOM70 antibody at 2 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of TOM70 in mouse brain tissue with TOM70 antibody at 2.5 ug/mL.)

Related Product Information for anti-TOM70 antibody

The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear. At least two isoforms of TOM70 are known to exist.

Product Categories/Family for anti-TOM70 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 54607135
• NCBI GeneID: 9868
• NCBI Accession #: NP_055635
• NCBI GenBank Nucleotide #: NM_014820.4
• Molecular Weight: 67,455 Da
• NCBI Official Full Name: mitochondrial import receptor subunit TOM70
• NCBI Official Synonym Full Names: translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
• NCBI Official Symbol: TOMM70A
• NCBI Protein Information: mitochondrial import receptor subunit TOM70
• UniProt Protein Name: Mitochondrial import receptor subunit TOM70
• Protein Family: Mitochondrial import receptor
• UniProt Gene Name: TOMM70A
• UniProt Synonym Gene Names: KIAA0719; TOM70
• UniProt Entry Name: TOM70_HUMAN

NCBI Description

This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]

Uniprot Description

TOMM70A: Receptor that accelerates the import of all mitochondrial precursor proteins. Belongs to the Tom70 family.

Protein type: Membrane protein, integral; Mitochondrial; Receptor, protein translocating

Chromosomal Location of Human Ortholog: 3q12.2

Cellular Component: mitochondrion; membrane; mitochondrial outer membrane translocase complex; integral to membrane

Molecular Function: protein binding; protein transmembrane transporter activity

Biological Process: cellular protein metabolic process; protein targeting to mitochondrion