Rabbit TNXB Polyclonal Antibody | anti-TNXB antibody

TNXB Polyclonal Antibody

Cat. Num. AAA2517557

• Gene Names: TNXB; XB; TNX; XBS; EDS3; HXBL; TENX; TN-X; VUR8; TNXB1; TNXB2; TNXBS
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: TNXB; Polyclonal Antibody; TNXB Polyclonal Antibody; XB; TNX; XBS; EDS3; HXBL; TENX; TN-X; TNXB1; TNXB2; TNXBS; anti-TNXB antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.5mg/mL (varies by lot)
• Sequence Length: 4242

• Applicable Applications for anti-TNXB antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Synthetic peptide of human TNXB
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain tissue using TNXB Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TNXB Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-TNXB antibody

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 188528648
• NCBI GeneID: 7148
• NCBI Accession #: NP_061978.6
• NCBI GenBank Nucleotide #: NM_019105.6
• Molecular Weight: 458,220 Da
• NCBI Official Full Name: tenascin-X isoform 1
• NCBI Official Synonym Full Names: tenascin XB
• NCBI Official Symbol: TNXB
• NCBI Official Synonym Symbols: XB; TNX; XBS; EDS3; HXBL; TENX; TN-X; VUR8; TNXB1; TNXB2; TNXBS
• NCBI Protein Information: tenascin-X; growth-inhibiting protein 45; hexabrachion-like protein; tenascin XB1; tenascin XB2
• UniProt Protein Name: Tenascin-X
• Protein Family: Tenascin
• UniProt Gene Name: TNXB
• UniProt Synonym Gene Names: HXBL; TNX; TNXB1; TNXB2; XB; TN-X
• UniProt Entry Name: TENX_HUMAN

NCBI Description

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TNXB: Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. Defects in TNXB are the cause of tenascin-X deficiency (TNXD). TNXD leads to an Ehlers-Danlos-like syndrome characterized by hyperextensible skin, hypermobile joints, and tissue fragility. Tenascin-X-deficient patients, however, lack atrophic scars, a major diagnostic criteria for classic Ehlers- Danlos. Delayed wound healing, which is also common in classic EDS, is only present in a subset of patients. Belongs to the tenascin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Extracellular matrix

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; fibrillar collagen; intracellular

Molecular Function: collagen binding; heparin binding; integrin binding

Biological Process: elastic fiber assembly; cell-cell adhesion; triacylglycerol metabolic process; collagen fibril organization; collagen metabolic process; cell-matrix adhesion; fibril organization and biogenesis; regulation of JNK activity; fatty acid metabolic process; cell adhesion; actin cytoskeleton organization and biogenesis

Disease: Ehlers-danlos-like Syndrome Due To Tenascin-x Deficiency; Vesicoureteral Reflux 8