Rabbit TNIP2 Polyclonal Antibody | anti-TNIP2 antibody

TNIP2 Polyclonal Antibody

Cat. Num. AAA2521325

• Gene Names: TNIP2; KLIP; ABIN2; FLIP1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: TNIP2; Polyclonal Antibody; TNIP2 Polyclonal Antibody; KLIP; ABIN2; FLIP1; anti-TNIP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.1mg/mL (varies by lot)
• Sequence Length: 346

• Applicable Applications for anti-TNIP2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human TNIP2
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of A431 cell using TNIP2 Polyclonal Antibody at dilution of 1:500)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer using TNIP2 Polyclonal Antibody at dilution of 1:35)

Related Product Information for anti-TNIP2 antibody

This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.

NCBI and Uniprot Product Information

• NCBI GI #: 635372911
• NCBI GeneID: 79155
• NCBI Accession #: NP_001278945.1
• NCBI GenBank Nucleotide #: NM_001292016.1
• Molecular Weight: 36,682 Da
• NCBI Official Full Name: TNFAIP3-interacting protein 2 isoform 3
• NCBI Official Synonym Full Names: TNFAIP3 interacting protein 2
• NCBI Official Symbol: TNIP2
• NCBI Official Synonym Symbols: KLIP; ABIN2; FLIP1
• NCBI Protein Information: TNFAIP3-interacting protein 2; A20-binding inhibitor of NF-kappaB activation-2; TNIP2; fetal liver LKB1-interacting protein
• UniProt Protein Name: TNFAIP3-interacting protein 2
• Protein Family: TNFAIP3-interacting protein
• UniProt Gene Name: TNIP2
• UniProt Synonym Gene Names: ABIN-2
• UniProt Entry Name: TNIP2_HUMAN

NCBI Description

This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

Uniprot Description

TNIP2: Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; polyubiquitin binding; protein kinase binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; protein stabilization; apoptosis; positive regulation of B cell activation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; toll-like receptor 3 signaling pathway; inflammatory response; positive regulation of macrophage activation; toll-like receptor 2 signaling pathway