Rabbit anti-Human TNFRSF21 Polyclonal Antibody | anti-TNFRSF21 antibody

TNFRSF21, ID (TNFRSF21, DR6, Tumor necrosis factor receptor superfamily member 21, Death receptor 6, CD358)

Cat. Num. AAA648028

• Gene Names: TNFRSF21; DR6; CD358; BM-018
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: TNFRSF21; Polyclonal Antibody; ID (TNFRSF21; DR6; Tumor necrosis factor receptor superfamily member 21; Death receptor 6; CD358); Anti -TNFRSF21; anti-TNFRSF21 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-TNFRSF21 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: TNFRSF21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-385 amino acids from the Central region of human TNFRSF21.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TNFRSF21 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TNFRSF21 antibody detected the TNFRSF21 protein (arrow).)

Related Product Information for anti-TNFRSF21 antibody

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.

Product Categories/Family for anti-TNFRSF21 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 48146497
• NCBI GeneID: 27242
• UniProt Accession #: O75509; Q0D2P5; Q96D86; B2RDI9
• Molecular Weight: 71,845 Da
• NCBI Official Full Name: TNFRSF21
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 21
• NCBI Official Symbol: TNFRSF21
• NCBI Official Synonym Symbols: DR6; CD358; BM-018
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 21; death receptor 6; TNFR-related death receptor 6
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 21
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF21
• UniProt Synonym Gene Names: DR6
• UniProt Entry Name: TNR21_HUMAN

NCBI Description

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]

Uniprot Description

Function: May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Subunit structure: Associates with TRADD. Interacts with N-APP

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein

Probable.

Tissue specificity: Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.

Sequence similarities: Contains 1 death domain.Contains 4 TNFR-Cys repeats.

Caution: It is uncertain whether Met-1 or Met-25 is the initiator.

Sequence caution: The sequence AAH10241.1 differs from that shown. Reason: Erroneous initiation.