Rabbit anti-Human, Mouse TNFRSF14 / CD270 / HVEM Polyclonal Antibody | anti-TNFRSF14 antibody

Rabbit Polyclonal to Human TNFRSF14 / CD270 / HVEM

Cat. Num. AAA240309

• Gene Names: TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: TNFRSF14 / CD270 / HVEM; Polyclonal Antibody; Rabbit Polyclonal to Human TNFRSF14 / CD270 / HVEM; Anti-TNFRSF14 / CD270 / HVEM Antibody (N-Terminus) IHC-plus; TNFRSF14; CD270; CD270 antigen; CD40-like protein; Herpesvirus entry mediator; Herpesvirus entry mediator A; HVEM; LIGHTR; Herpes virus entry mediator A; TR2; ATAR; HVEA; Human TNFRSF14; anti-TNFRSF14 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: 15 amino acid peptide from near the amino terminus of human TNFRSF14
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 283

• Applicable Applications for anti-TNFRSF14 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Target Species: Human
• Immunogen Description: Synthetic peptide from human TNFRSF14.
• Immunogen Type: Synthetic peptide
• Immunogen: TNFRSF14 / CD270 / HVEM antibody was raised against synthetic peptide from human TNFRSF14.
• Antigen Modification: N-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-TNFRSF14 / CD270 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of TNFRSF14 in Mouse Thymus cells with TNFRSF14 antibody at 10 ug/ml.)

Western Blot (WB)

(Western blot of TNFRSF14 in mouse thymus tissue lysate with TNFRSF14 antibody at (A) 1 and (B) 2 ug/ml.)

Related Product Information for anti-TNFRSF14 antibody

HVEM (Herpes virus entry mediator) is a member of the tumor necrosis factor receptor family. This family of receptors plays a central role in the development of the immune system. HVEM has been shown to mediate HSV entry into activated T cells, in addition to modulating the activation of nuclear factor NF-kB (a transcriptional activator of multiple immuno modulatory and inflammatory genes) and transcription factor AP-1 (a regulator of cellular stress-response genes).

Product Categories/Family for anti-TNFRSF14 antibody

Family: TNF Receptor

NCBI and Uniprot Product Information

• NCBI GI #: 23200041
• NCBI GeneID: 8764
• NCBI Accession #: NP_003811.2
• NCBI GenBank Nucleotide #: NM_003820.3
• UniProt Accession #: Q92956; Q6IB95; Q8N634; Q8WXR1; Q96J31; Q9UM65; B3KW30; B9DI89
• Molecular Weight: 21,351 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 14 isoform 1
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 14
• NCBI Official Symbol: TNFRSF14
• NCBI Official Synonym Symbols: TR2; ATAR; HVEA; HVEM; CD270; LIGHTR
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 14; CD40-like protein; herpes virus entry mediator A; tumor necrosis factor receptor-like gene2; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 14
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF14
• UniProt Synonym Gene Names: HVEA; HVEM; Herpesvirus entry mediator A; HveA; TR2
• UniProt Entry Name: TNR14_HUMAN

NCBI Description

This gene encodes a member of the TNF (tumor necrosis factor) receptor superfamily. The encoded protein functions in signal transduction pathways that activate inflammatory and inhibitory T-cell immune response. It binds herpes simplex virus (HSV) viral envelope glycoprotein D (gD), mediating its entry into cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

TNFRSF14: Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

Protein type: Membrane protein, integral; Receptor, misc.; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1p36.32

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: viral receptor activity; protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; entry of virus into host cell; defense response to Gram-positive bacterium; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; T cell costimulation; positive regulation of cytokine secretion during immune response; negative regulation of alpha-beta T cell proliferation; immune response; defense response to Gram-negative bacterium