Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded mouse bone using TNFRSF11B Polyclonal Antibody at dilution of 1:200.)
Rabbit anti-Mouse, Rat TNFRSF11B Polyclonal Antibody | anti-TNFRSF11B antibody
TNFRSF11B Polyclonal Antibody
Gene Names
Tnfrsf11b; Opg; TR1; OCIF
Reactivity
Mouse, Rat
Applications
Immunohistochemistry
Purity
Affinity Purification
Synonyms
TNFRSF11B; Polyclonal Antibody; TNFRSF11B Polyclonal Antibody; MGC29565; OCIF; OPG; Osteoclastogenesis inhibitory factor; Osteoprotegerin; PDB5; TNF receptor superfamily member 11b; TNFRSF 11B; TR 1; TR1; TR11B; Tumor necrosis factor receptor superfamily member 11B; anti-TNFRSF11B antibody
Host
Rabbit
Reactivity
Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 100 mug/ml BSA and 50% glycerol.
Concentration
0.93 mg/mL (varies by lot)
Sequence Length
401
Applicable Applications for anti-TNFRSF11B antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1:200
Immunogen
KLH conjugated synthetic peptide corresponding to Mouse Osteoprotegerin
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded mouse bone using TNFRSF11B Polyclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded mouse bone using TNFRSF11B Polyclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded Rat tooth using TNFRSF11B Polyclonal Antibody at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded Rat tooth using TNFRSF11B Polyclonal Antibody at dilution of 1:200.)
Related Product Information for anti-TNFRSF11B antibody
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Product Categories/Family for anti-TNFRSF11B antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
45,923 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 11B
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
NCBI Official Symbol
Tnfrsf11b
NCBI Official Synonym Symbols
Opg; TR1; OCIF
NCBI Protein Information
tumor necrosis factor receptor superfamily member 11B
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 11B
Protein Family
UniProt Gene Name
Tnfrsf11b
UniProt Synonym Gene Names
Ocif; Opg
Uniprot Description
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Research Articles on TNFRSF11B
Similar Products
Product Notes
The TNFRSF11B tnfrsf11b (Catalog #AAA2556088) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TNFRSF11B Polyclonal Antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TNFRSF11B can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:200. Researchers should empirically determine the suitability of the TNFRSF11B tnfrsf11b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNFRSF11B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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