Western Blot (WB)
(Figure 1: Western blot analysis using TNFRSF11B mAb against HEK293 (1) and TNFRSF11B-hIgGFc transfected HEK293 (2) cell lysate.)
Mouse anti-Human TNFRSF11B Antibody | anti-TNFRSF11B antibody
TNFRSF11B Antibody
IF: 1:200-1:1000
FC: 1:200-1:400
ELISA: 1:10000
Western Blot (WB)
(Figure 1: Western blot analysis using TNFRSF11B mAb against HEK293 (1) and TNFRSF11B-hIgGFc transfected HEK293 (2) cell lysate.)
Western Blot (WB)
(Figure 1: Western blot analysis using TNFRSF11B mAb against HEK293 (1) and TNFRSF11B-hIgGFc transfected HEK293 (2) cell lysate.)
Immunofluorescence (IF)
(Figure 2: Immunofluorescence analysis of HL-60 cells using TNFRSF11B mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.)
Immunofluorescence (IF)
(Figure 2: Immunofluorescence analysis of HL-60 cells using TNFRSF11B mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.)
Flow Cytometry (FC/FACS)
(Figure 3: Flow cytometric analysis of HL-60 cells using TNFRSF11B mouse mAb (green) and negative control (purple).)
Flow Cytometry (FC/FACS)
(Figure 3: Flow cytometric analysis of HL-60 cells using TNFRSF11B mouse mAb (green) and negative control (purple).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Research Articles on TNFRSF11B
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Product Notes
The TNFRSF11B tnfrsf11b (Catalog #AAA850438) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TNFRSF11B Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TNFRSF11B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF), Flow Cytometry (FC/FACS), ELISA (EIA). WB: 1:500-1:2000 IF: 1:200-1:1000 FC: 1:200-1:400 ELISA: 1:10000. Researchers should empirically determine the suitability of the TNFRSF11B tnfrsf11b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNFRSF11B, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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