Rabbit anti-Mouse TNFAIP8L2 Polyclonal Antibody | anti-TNFAIP8L2 antibody

TNFAIP8L2 Polyclonal Antibody

Cat. Num. AAA3010102

• Gene Names: TNFAIP8L2; TIPE2
• Reactivity: Mouse
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: TNFAIP8L2; Polyclonal Antibody; TNFAIP8L2 Polyclonal Antibody; TIPE2; anti-TNFAIP8L2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TNFAIP8L2 polyclonal antibody detects endogenous levels of TNFAIP8L2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 184

• Applicable Applications for anti-TNFAIP8L2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human TNFAIP8L2
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of various cell lines, using TNFAIP8L2 antibody at 1:3000 dilution.)

Related Product Information for anti-TNFAIP8L2 antibody

TNFalpha-IP 8L2 (tumor necrosis factor, alpha-induced protein 8-like 2), also known as TIPE2, is a 184 amino acid protein that shares 94% identity with its mouse counterpart and belongs to the TNFAIP8 family. Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin, TNFalpha-IP 8L2 plays a role in maintaining immune homeostasis, specifically by acting as a negative regulator of both innate and adaptive immunity. In addition, TNFalpha-IP 8L2 functions as a negative regulator of T cell receptor function and is thought to promote FAS-induced apoptosis. The gene encoding TNFalpha-IP 8L2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3, 000 genes and comprises nearly 8% of the human genome.

NCBI and Uniprot Product Information

• NCBI GI #: 157389001
• NCBI GeneID: 79626
• NCBI Accession #: NP_078851.2
• NCBI GenBank Nucleotide #: NP_078851.2
• UniProt Accession #: Q6P589
• Molecular Weight: 20kDa
• NCBI Official Full Name: tumor necrosis factor alpha-induced protein 8-like protein 2
• NCBI Official Synonym Full Names: TNF alpha induced protein 8 like 2
• NCBI Official Symbol: TNFAIP8L2
• NCBI Official Synonym Symbols: TIPE2
• NCBI Protein Information: tumor necrosis factor alpha-induced protein 8-like protein 2
• UniProt Protein Name: Tumor necrosis factor alpha-induced protein 8-like protein 2
• Protein Family: Tumor necrosis factor alpha-induced protein 8-like protein
• UniProt Gene Name: TNFAIP8L2
• UniProt Synonym Gene Names: TIPE2; TNF alpha-induced protein 8-like protein 2
• UniProt Entry Name: TP8L2_HUMAN

Uniprot Description

TNFAIP8L2: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytoplasm

Molecular Function: protein binding

Biological Process: negative regulation of inflammatory response; innate immune response; negative regulation of T cell activation