Western Blot (WB)
(Western blot analysis of TNF-R1: Lane 1: MW marker, Lane 2: Hela (HS), Lane 3: Jurkat)
Rabbit TNF receptor 1 Polyclonal Antibody | anti-Tumor necrosis factor receptor 1; TNF-R1 antibody
TNF receptor 1 polyclonal antibody
Western Blot (1:1,000, ECL)
Suggested dilutions/conditions may not be available for all applications.
Detects a band of 55kDa by Western blot.
Western Blot (WB)
(Western blot analysis of TNF-R1: Lane 1: MW marker, Lane 2: Hela (HS), Lane 3: Jurkat)
Western Blot (WB)
(Western blot analysis of TNF-R1: Lane 1: MW marker, Lane 2: Hela (HS), Lane 3: Jurkat)
NCBI and Uniprot Product Information
Uniprot Description
TNF-R1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, cytokine; Membrane protein, integral
Cellular Component: axon; cell surface; cytosol; extracellular space; Golgi apparatus; Golgi membrane; integral to membrane; integral to plasma membrane; lipid raft; membrane; mitochondrion; nucleus; plasma membrane; protein complex; receptor complex; synapse
Molecular Function: protease binding; protein binding; protein complex binding; tumor necrosis factor binding; tumor necrosis factor receptor activity
Biological Process: apoptosis; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; defense response; defense response to bacterium; DNA damage response, signal transduction resulting in induction of apoptosis; immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; negative regulation of apoptosis; negative regulation of inflammatory response; negative regulation of interleukin-6 production; positive regulation of angiogenesis; positive regulation of inflammatory response; positive regulation of neuron apoptosis; positive regulation of protein import into nucleus, translocation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of Stat1 protein; prostaglandin metabolic process; protein heterooligomerization; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway
Research Articles on Tumor necrosis factor receptor 1; TNF-R1
Similar Products
Product Notes
The Tumor necrosis factor receptor 1; TNF-R1 tnfrsf1a (Catalog #AAA565174) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TNF receptor 1 polyclonal antibody reacts with Human, Mouse, Rat, Bovine, Dog, Drosophila, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus, Yeast and may cross-react with other species as described in the data sheet. AAA Biotech's TNF receptor 1 can be used in a range of immunoassay formats including, but not limited to, Immmunohistochemistry (IHC) (PS), Immunoprecipitation (IP), Western Blot (WB). Immunoprecipitation (12.5ug/ml) Western Blot (1:1,000, ECL) Suggested dilutions/conditions may not be available for all applications. Detects a band of 55kDa by Western blot. Researchers should empirically determine the suitability of the Tumor necrosis factor receptor 1; TNF-R1 tnfrsf1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNF receptor 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
