Western Blot (WB)
(Western blot analysis of TNF-R1 expression in rat brain tissue.)
Rabbit TNF-R1 Polyclonal Antibody | anti-TNF-R1 antibody
TNF-R1 Antibody
Immunohistochemistry (2.5 ug/ml).
However, the optimal conditions should be determined individually.
Blocking peptide (Cat. MBS843611) is available separately.
Western Blot (WB)
(Western blot analysis of TNF-R1 expression in rat brain tissue.)
Western Blot (WB)
(Western blot analysis of TNF-R1 expression in rat brain tissue.)
NCBI and Uniprot Product Information
Uniprot Description
TNF-R1: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Cellular Component: Golgi apparatus; extracellular space; protein complex; cell surface; mitochondrion; integral to membrane; cytosol; lipid raft; Golgi membrane; membrane; axon; plasma membrane; synapse; intracellular; nucleus; receptor complex
Molecular Function: protein binding; tumor necrosis factor receptor activity; protease binding; protein complex binding; tumor necrosis factor binding
Biological Process: positive regulation of protein import into nucleus, translocation; apoptosis; protein heterooligomerization; cytokine and chemokine mediated signaling pathway; programmed cell death; defense response; signal transduction; positive regulation of tumor necrosis factor production; prostaglandin metabolic process; regulation of apoptosis; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of angiogenesis; cell surface receptor linked signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of inflammatory response; positive regulation of neuron apoptosis; defense response to bacterium; negative regulation of interleukin-6 production; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of apoptosis; positive regulation of inflammatory response
Research Articles on TNF-R1
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Product Notes
The TNF-R1 tnfrsf1a (Catalog #AAA840939) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TNF-R1 Antibody reacts with Human, Mouse, Rat, Rabbit, Monkey, Hamster, Pig, Bovine, Canine, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's TNF-R1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: (0.5-4 ug/ml) Immunohistochemistry (2.5 ug/ml). However, the optimal conditions should be determined individually. Blocking peptide (Cat. MBS843611) is available separately. Researchers should empirically determine the suitability of the TNF-R1 tnfrsf1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNF-R1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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