Rabbit anti-Human TMEM43 Polyclonal Antibody | anti-TMEM43 antibody

TMEM43, ID (TMEM43, Transmembrane protein 43, Protein LUMA) (APC)

Cat. Num. AAA6356461

• Gene Names: TMEM43; LUMA; ARVC5; ARVD5; EDMD7
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TMEM43; Polyclonal Antibody; ID (TMEM43; Transmembrane protein 43; Protein LUMA) (APC); Protein LUMA; anti-TMEM43 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-TMEM43 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: TMEM43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-223 amino acids from the Central region of human TMEM43.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(TMEM43 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TMEM43 antibody detected the TMEM43 protein (arrow).)

Immunohistochemistry (IHC)

(TMEM43 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TMEM43 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-TMEM43 antibody

This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.

Product Categories/Family for anti-TMEM43 antibody

Antibodies; Transmembrane Proteins

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Barahona-Dussault, C., et al. Clin. Genet. 77(1):37-48(2010). Hodgkinson, K., et al. Genet. Med. 11(12):859-865(2009). Merner, N.D., et al. Am. J. Hum. Genet. 82(4):809-821(2008). Bengtsson, L., et al. J. Cell. Sci. 121 (PT 4), 536-548 (2008).

NCBI and Uniprot Product Information

• NCBI GI #: 13236587
• NCBI GeneID: 79188
• NCBI Accession #: NP_077310.1
• NCBI GenBank Nucleotide #: NM_024334.2
• UniProt Accession #: Q9BTV4; Q7L4N5; Q8NC30; Q96A63; Q96F19; Q96JX0; Q9H076
• Molecular Weight: 44,876 Da
• NCBI Official Full Name: transmembrane protein 43
• NCBI Official Synonym Full Names: transmembrane protein 43
• NCBI Official Symbol: TMEM43
• NCBI Official Synonym Symbols: LUMA; ARVC5; ARVD5; EDMD7
• NCBI Protein Information: transmembrane protein 43
• UniProt Protein Name: Transmembrane protein 43
• Protein Family: Transmembrane protein
• UniProt Gene Name: TMEM43
• UniProt Synonym Gene Names: UNQ2564/PRO6244
• UniProt Entry Name: TMM43_HUMAN