Western Blot (WB)
(Western blot analysis of TMEFF2 using RAW264.7 whole cell lysates)
Rabbit anti-Human TMEFF2 Polyclonal Antibody | anti-TMEFF2 antibody
TMEFF2 Antibody
Gene Names
TMEFF2; TR; HPP1; TPEF; TR-2; TENB2; CT120.2
Reactivity
Human
Applications
Western Blot, ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
TMEFF2; Polyclonal Antibody; TMEFF2 Antibody; Cancer/testis antigen family 120 member 2; CT120.2; HPP 1; HPP1; Hyperplastic polyposis protein 1; TEFF 2; TEFF2; TEFF2_HUMAN; TENB 2; TENB2; Tomoregulin; Tomoregulin-2; TPEF; TR 2; TR; TR-2; Transmembrane protein containing epidermal growth factor and follistatin domains; Transmembrane protein TENB2; Transmembrane protein with EGF like and two follistatin like domains 2; Transmembrane protein with EGF-like and two follistatin-like domains; anti-TMEFF2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
TMEFF2 antibody detects endogenous levels of total TMEFF2
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
346
Applicable Applications for anti-TMEFF2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:1000-3000
Immunogen
A synthesized peptide derived from human TMEFF2
Subcellular Location
Secreted and Membrane.
Tissue Specificity
Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate.
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog
Similarity
Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%)
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of TMEFF2 using RAW264.7 whole cell lysates)
Western Blot (WB)
(Western blot analysis of TMEFF2 using RAW264.7 whole cell lysates)
Related Product Information for anti-TMEFF2 antibody
Function: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
Post-translational Modifications: N-glycosylated. Contains chondroitin sulfate glycosaminoglycans. A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
Similarity: Belongs to the tomoregulin family.
Post-translational Modifications: N-glycosylated. Contains chondroitin sulfate glycosaminoglycans. A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17.
Similarity: Belongs to the tomoregulin family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 41 kDa
Predicted: 42 kDa
Predicted: 42 kDa
NCBI Official Full Name
tomoregulin-2 isoform 2
NCBI Official Synonym Full Names
transmembrane protein with EGF like and two follistatin like domains 2
NCBI Official Symbol
TMEFF2
NCBI Official Synonym Symbols
TR; HPP1; TPEF; TR-2; TENB2; CT120.2
NCBI Protein Information
tomoregulin-2
UniProt Protein Name
Tomoregulin-2
Protein Family
UniProt Gene Name
TMEFF2
UniProt Synonym Gene Names
HPP1; TENB2; TPEF; TR-2
NCBI Description
This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Description
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
Research Articles on TMEFF2
Similar Products
Product Notes
The TMEFF2 tmeff2 (Catalog #AAA9608769) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TMEFF2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TMEFF2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:1000-3000. Researchers should empirically determine the suitability of the TMEFF2 tmeff2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TMEFF2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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